{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:11:05Z","timestamp":1782623465769,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jinan Clinical Medical Science and Technology Innovation Plan","award":["201907002"],"award-info":[{"award-number":["201907002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2020,11,20]]},"abstract":"<jats:p>Aim. The aim of this study was to evaluate the levels of kisspeptin and AMH in children with PT or CPP or controls to provide a reference for diagnosis and prognosis. Methods. 38 Chinese children with central precocious puberty (CPP), 38 Chinese children with premature thelarche (PT), and 75 controls were recruited. Results. In CPP girls, AMH levels decreased significantly compared to control girls at T2 stage. Compared with the PT and control groups, AMH is the lowest in girls in the CPP group at T3 stage. Kisspeptin decreased significantly in girls in the PT group and increased significantly in girls in the control group from T2 stage to T3 stage. At T3 stage, kisspeptin was significantly higher in girls in the CPP and control groups than in the PT group. In the control group, kisspeptin was significantly higher in boys than in girls at T2 stage. AMH and height were negatively correlated in the girls group. Conclusions. Kisspeptin and AMH have a unique significance in the auxiliary diagnosis, the differential diagnosis, the treatment, and prognosis of sexual puberty disorder.<\/jats:p>","DOI":"10.1155\/2020\/3126309","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T20:05:05Z","timestamp":1605989105000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Serum Kisspeptin and AMH Levels Are Good References for Precocious Puberty Progression"],"prefix":"10.1155","volume":"2020","author":[{"given":"Jiang","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, China"},{"name":"Department of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-1097","authenticated-orcid":true,"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1753-3105","authenticated-orcid":true,"given":"Kailin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-5328","authenticated-orcid":true,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Interventional Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-6829","authenticated-orcid":true,"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6803-1792","authenticated-orcid":true,"given":"Yanfeng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"272","article-title":"Recommendations for the diagnosis and treatment of central precocious puberty","volume":"41","author":"Group of Endocrine and Genetic Metabolic Diseases","year":"2003","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(15)00380-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2016.21.2.66"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6790794"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.12.011"},{"issue":"6","key":"6","first-page":"422","article-title":"Kisspeptin permits the sexual development of female rats with normal and precocious puberty but is not a trigger for it","volume":"38","author":"W. 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