{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:25:34Z","timestamp":1785032734152,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","award":["36619211"],"award-info":[{"award-number":["36619211"]}],"id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,9,7]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Stroke activates the immune system and induces brain infiltration by immune cells, aggravating brain injury. Poststroke immunomodulation via (S1P-)receptor modulation is beneficial; however, the S1P-modulator in clinical use (FTY-720) is unspecific, and undesirable side effects have been reported. Previously, we tested effects of a novel selective S1P-receptor modulator, Siponimod, on ICH-induced brain injury in acute stage of the disease. In the current study, we investigated whether protective effects of Siponimod, evaluated in a short-term study, will protect the brain of ICH animals at long term as well. <jats:italic>Methods.<\/jats:italic> 134 C57BL\/6N mice were divided into sham and ICH-operated groups. Collagenase model of ICH was employed. ICH animals were divided into Siponimod treated and nontreated. Dose- and time-dependent effects of Siponimod were investigated. Contraplay between development of brain injury and the number of lymphocytes infiltrating the brain was investigated by forelimb placing, T-Maze test, brain water content calculation, MRI scanning, and immunostaining. <jats:italic>Results<\/jats:italic>. Depending on the therapeutic strategy, Siponimod attenuated the development of brain edema, decreased ICH-induced ventriculomegaly and improved neurological functions of animals after ICH. It was associated with less lymphocytes in the brain of ICH animals. <jats:italic>Conclusion<\/jats:italic>. Siponimod is able to decrease the brain injury and improves neurological functions of animals after ICH.<\/jats:p>","DOI":"10.1155\/2020\/3214350","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T23:31:07Z","timestamp":1599521467000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["A Sphingosine-1-Phosphate Receptor Modulator Attenuated Secondary Brain Injury and Improved Neurological Functions of Mice after ICH"],"prefix":"10.1155","volume":"2020","author":[{"given":"T.","family":"Bobinger","sequence":"first","affiliation":[{"name":"Department of Neurology of the Friedrich-Alexander-University Erlangen-Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"B\u00e4uerle","sequence":"additional","affiliation":[{"name":"Department of Radiology of the Friedrich-Alexander-University Erlangen-Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Seyler","sequence":"additional","affiliation":[{"name":"Department of Radiology of the Friedrich-Alexander-University Erlangen-Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6409-0664","authenticated-orcid":true,"given":"S.","family":"v Horsten","sequence":"additional","affiliation":[{"name":"Department of Experimental Therapy, University Hospital Erlangen, and Preclinical Experimental Animal Center, Friedrich-Alexander-University Erlangen-Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8487-1238","authenticated-orcid":true,"given":"S.","family":"Schwab","sequence":"additional","affiliation":[{"name":"Department of Neurology of the Friedrich-Alexander-University Erlangen-Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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