{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:47:22Z","timestamp":1793677642644,"version":"4.5.1"},"reference-count":229,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2020,9,10]]},"abstract":"<jats:p>Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release from the bone. Thus, calcitonin was said as a primary regulator of the bone resorption process. This is the reason why calcitonin has been used widely in clinics for the treatment of bone disorders such as osteoporosis, hypercalcemia, and Paget\u2019s disease. However, presently calcitonin usage is declined due to the development of efficacious formulations of new drugs. Calcitonin gene-related peptides and several other peptides such as intermedin, amylin, and adrenomedullin (ADM) are categorized in calcitonin family. These peptides are known for the structural similarity with calcitonin. Aside from having a similar structure, these peptides have few overlapping biological activities and signal transduction action through related receptors. However, several other activities are also present that are peptide specific.<jats:italic>In vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>studies documented the posttreatment effects of calcitonin peptides, i.e., positive effect on bone osteoblasts and their formation and negative effect on osteoclasts and their resorption. The recent research studies carried out on genetically modified mice showed the inhibition of osteoclast activity by amylin, while astonishingly calcitonin plays its role by suppressing osteoblast and bone turnover. This article describes the review of the bone, the activity of the calcitonin family of peptides, and the link between them.<\/jats:p>","DOI":"10.1155\/2020\/3236828","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T23:33:33Z","timestamp":1599780813000},"page":"1-20","source":"Crossref","is-referenced-by-count":60,"title":["Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations"],"prefix":"10.1155","volume":"2020","author":[{"given":"Jingbo","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Fengcheng People\u2019s Hospital, Fengcheng, Jiangxi 331100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of the Second Orthopedics, Hongdu Hospital of Traditional Chinese Medicine Affiliated to Jiangxi University of Traditional Chinese Medicine, Nanchang Hongdu Traditional Chinese Medicine Hospital, Nanchang, Jiangxi 330008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaeema","family":"Kanwal","sequence":"additional","affiliation":[{"name":"Ameer Ud Din Medical College, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Pu\u2019ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xi\u2019an International Medical Center Hospital, Xi\u2019an, Shaanxi 710100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal Abdalla","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Ajman University, Ajman 346, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Ya\u2019an People\u2019s Hospital, Ya\u2019an, Sichuan 625000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal Ali","family":"Buabeid","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Ajman University, Ajman 346, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El-Shaimaa A.","family":"Arafa","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Ajman University, Ajman 346, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-0059","authenticated-orcid":true,"given":"Qingshan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Third Hospital of Shandong Province, Jinan, Shandong 250031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","volume-title":"Regulation of calcium and magnesium","year":"2013"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06057"},{"key":"3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0021-9258(18)85007-4","volume":"63","year":"1925","journal-title":"Journal of Biological Chemistry"},{"key":"4","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1016\/S0021-9258(18)69644-9","volume":"234","year":"1959","journal-title":"The Journal of Biological Chemistry"},{"key":"5","first-page":"46","volume":"9","year":"1957","journal-title":"Clinical Orthopaedics"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/193381a0"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1210\/endo-70-5-638"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1126\/science.146.3642.412"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3702.1465"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(66)91577-7"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/s8756-3282(02)00688-9"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/220984a0"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.15.5064"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/08977190410001728033"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/271501a0"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/290063a0"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/304129a0"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1126\/science.2994212"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/bf00273453"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202807"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-017-0246-8"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1812-6"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6215"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8628"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.11.3881"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05367.x"},{"key":"27","doi-asserted-by":"crossref","first-page":"19279","DOI":"10.1073\/pnas.1305517110","volume":"110","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2009"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.41.4.508"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.40.12.1701"},{"issue":"9","key":"31","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/jbmr.5650070915","volume":"7","year":"1992","journal-title":"Journal of Bone and Mineral Research"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/s1054-3589(05)52002-7"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03129.x"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.39.6.752"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/bf00404025"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.5.639"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1007\/bf00500385"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1451"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10046"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10045"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.2174\/13892037113149990052"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(03)01368-1"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m305332200"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01530.x"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m207970200"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2009.06.012"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1042\/bj2550377"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.2.208"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13496"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01525.x"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.4.e730"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.274.5.e827"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.64.2.771"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1007\/bf01927568"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-016-0791-6"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0490-1"},{"key":"57","first-page":"265","volume":"104","year":"1991","journal-title":"Transactions of the Association of American Physicians"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.12.7588285"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1172\/jci117970"},{"issue":"2","key":"60","first-page":"246","volume":"46","year":"1994","journal-title":"Molecular Pharmacology"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1210\/mend.7.6.8395656"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/s8756-3282(99)00094-0"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90230-o"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1042\/cs0850385"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1047"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.273.6.e1113"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.06.015"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1038\/30666"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/s1056-8719(00)00074-5"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1124\/mol.56.1.235"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.6.6930"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1124\/pr.54.2.233"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.08.007"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010715-103120"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2015.1128875"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.04.018"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m413786200"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1735"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.a116.751362"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092042"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1660213"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.021"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1210\/endo-79-6-1033"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1210\/endo-76-1-103"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1210\/endo-79-3-655"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.203"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1007\/bf02555747"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(84)90427-2"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.12.8536"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.2174\/1381612023393341"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21674"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1020281"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711360104"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1360007"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1260473"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.01.014"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1016\/s8756-3282(02)00834-7"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.3.8603572"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1016\/s8756-3282(01)00494-x"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110406"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1677\/joe-07-0338"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1210\/endo-118-1-46"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(84)90118-5"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.11.029"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-9781(00)00185-6"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1016\/s8756-3282(97)00142-7"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1163"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1097\/00019616-199905000-00004"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-186"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799x-5-83"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1042\/cs0810803"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(89)92391-7"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(89)91028-3"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1615\/critrevneurobiol.v11.i2-3.40"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1990.sp003429"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200312135"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(93)90244-5"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041530103"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.275.4.e694"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1650663"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1700251"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23256"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0832-0"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1002\/art.33426"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4328"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1993.sp003679"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(91)91345-d"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6420.812"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90961-0"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1210\/endo-90-3-752"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.1172\/jci117634"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00280-8"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1172\/jci110319"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-1-159"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00307.2002"},{"key":"136","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.07.003"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650010109"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070903"},{"key":"139","doi-asserted-by":"publisher","DOI":"10.1007\/bf02555739"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650061016"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040220"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00274.2003"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1998.0415"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00016-7"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.8.1302"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(00)00872-4"},{"key":"147","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-9781(97)00199-x"},{"key":"148","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22266"},{"key":"149","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.41"},{"key":"150","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(93)90385-l"},{"key":"151","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2318-6"},{"key":"152","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5117"},{"key":"153","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-015-0630-8"},{"key":"154","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5048"},{"key":"155","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-9781(97)00056-9"},{"key":"156","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.020"},{"key":"157","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.5.e779"},{"key":"158","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.08.053"},{"key":"159","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.02.030"},{"key":"160","doi-asserted-by":"publisher","DOI":"10.1007\/bf00298745"},{"key":"161","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.5.958"},{"key":"162","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.11.013"},{"key":"163","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-010-9338-3"},{"key":"164","doi-asserted-by":"publisher","DOI":"10.1016\/s0196-9781(02)00259-0"},{"key":"165","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.5.8152"},{"key":"166","doi-asserted-by":"publisher","DOI":"10.2209\/tdcpublication.53.203"},{"key":"167","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21294"},{"key":"168","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23311"},{"key":"169","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1567"},{"key":"170","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0888-7"},{"key":"171","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.10.007"},{"key":"172","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1607948"},{"key":"173","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1708322"},{"key":"174","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.12.2014"},{"key":"175","doi-asserted-by":"publisher","DOI":"10.1172\/jci6800"},{"key":"176","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.02.018"},{"key":"177","doi-asserted-by":"publisher","DOI":"10.1530\/joe-13-0524"},{"key":"178","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2014.11.005"},{"key":"179","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16008"},{"key":"180","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198708273170904"},{"key":"181","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1340141"},{"key":"182","doi-asserted-by":"publisher","DOI":"10.1385\/endo:21:3:201"},{"key":"183","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0599"},{"key":"184","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1869"},{"key":"185","doi-asserted-by":"publisher","DOI":"10.1172\/jci200214218"},{"key":"186","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.040915"},{"key":"187","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.02.013"},{"key":"188","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060820"},{"key":"189","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113959"},{"key":"190","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.7.1067"},{"key":"191","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080310"},{"key":"192","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2449"},{"key":"193","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.09.013"},{"key":"194","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1616"},{"key":"195","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1345"},{"key":"196","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-005-0286-2"},{"key":"197","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-2364-5_5"},{"key":"198","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.615"},{"key":"199","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m703544200"},{"key":"200","doi-asserted-by":"publisher","DOI":"10.1172\/jci33302"},{"key":"201","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102356"},{"key":"202","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705974104"},{"key":"203","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00280"},{"key":"204","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.07.037"},{"key":"205","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0400"},{"key":"206","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-238998"},{"key":"207","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1211376"},{"key":"208","doi-asserted-by":"publisher","DOI":"10.1177\/1060028013509233"},{"issue":"2","key":"209","first-page":"155","volume":"3","year":"1985","journal-title":"Clinical and Experimental Rheumatology"},{"key":"210","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-8-5"},{"key":"211","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2016.1175436"},{"key":"212","doi-asserted-by":"publisher","DOI":"10.1007\/bf01622285"},{"key":"213","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010372625"},{"key":"214","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6862.1124"},{"key":"215","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(88)91712-6"},{"key":"216","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(96)00084-1"},{"key":"217","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(00)00490-3"},{"key":"218","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(00)00539-8"},{"key":"219","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.050411"},{"key":"220","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.07.019"},{"key":"221","year":"2015"},{"key":"222","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh243"},{"key":"223","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/lds038"},{"key":"224","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.01.014"},{"key":"225","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2012.760549"},{"key":"226","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060830"},{"key":"227","doi-asserted-by":"publisher","DOI":"10.1002\/art.22797"},{"key":"228","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.11.004"},{"key":"229","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.08.003"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2020\/3236828.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2020\/3236828.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2020\/3236828.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T16:10:14Z","timestamp":1723565414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ije\/2020\/3236828\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":229,"alternative-id":["3236828","3236828"],"URL":"https:\/\/doi.org\/10.1155\/2020\/3236828","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,10]]}}}