{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:57:33Z","timestamp":1773403053289,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["19A350003"],"award-info":[{"award-number":["19A350003"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Obesity causes a variety of metabolic alterations that may contribute to abnormalities of the cardiac structure and function (obesity cardiomyopathy). In previous works, we have shown that pentamethylquercetin (PMQ) significantly improved metabolic disorders in obese mice and it inhibited pressure overload\u2010induced cardiac remodeling in mice. However, its potential benefit in obesity cardiomyopathy remains unclear. The aim of this study was to investigate the effects of PMQ on cardiac remodeling in obese mice. <jats:italic>Methods<\/jats:italic>. We generated a monosodium glutamate\u2010induced obese (MSG\u2010IO) model in mice, which were treated with PMQ (5, 10, and 20\u2009mg\/kg) for 16 weeks consecutively. We examined the metabolic parameters and observed cardiac remodeling by performing cardiac echocardiography and Masson\u2019s staining. The expression levels of molecules associated with the endogenous antioxidant system, including the sestrins\/kelch\u2010like ECH\u2010associated protein 1 (Keap1)\/Nuclear factor (erythroid\u2010derived 2)\u2010like 2 (Nrf2) signaling pathway, were analyzed by western blotting and immunofluorescent staining. <jats:italic>Results<\/jats:italic>. We found that PMQ treatment significantly ameliorated obesity phenotypes and improved metabolic disorders in MSG\u2010IO mice. PMQ decreased the heart wall thickness and attenuated cardiac fibrosis. Further study revealed that the protective effects of PMQ might be mediated by promoting Keap1 degradation and augmenting sestrins expression and Nrf2 nuclear translocation. <jats:italic>Conclusion<\/jats:italic>. Our findings indicated that PMQ ameliorated cardiac remodeling in obese mice by targeting the sestrins\/Keap1\/Nrf2 signaling pathway.<\/jats:p>","DOI":"10.1155\/2020\/3243906","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T23:31:32Z","timestamp":1580513492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins\/Keap1\/Nrf2 Pathway in MSG\u2010Induced Obese 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