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Curcumin is the most active ingredient of turmeric with anti\u2010inflammation and antioxidation effects. Here, the effect of curcumin on aldosterone\u2010induced C\u2010reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored. Primary rat vascular smooth muscle cells and hyperaldosteronism model rats were used in this study. The amount of C\u2010reactive protein, reactive oxygen species, and the signaling pathway\u2010related molecules generated were estimated. We found that curcumin inhibited aldosterone\u2010induced C\u2010reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species\u2010ERK1\/2 signal pathway. The results provide new evidence for the potential anti\u2010inflammatory and cardiovascular protective effects of curcumin.<\/jats:p>","DOI":"10.1155\/2020\/3245653","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T23:37:09Z","timestamp":1596843429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Curcumin Suppresses Aldosterone\u2010Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS\u2010ERK1\/2 Signaling Pathway"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-827X","authenticated-orcid":false,"given":"Xiaolu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-7506","authenticated-orcid":false,"given":"Juntian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouzhu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-09-0706"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-013-8384-0"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.20.9.2094"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15454"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft402"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs1030425"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2014.08.003"},{"key":"e_1_2_9_8_2","first-page":"7","volume-title":"Natural Product Drug Discovery 2019","author":"Fern\u00e1ndez-Moriano C.","year":"2019"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.06.021"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000061916.95736.e5"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc3601.095576"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46401-5_3"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2019.17.2"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1721727x17735261"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2008.01447.x"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.24"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.03.045"},{"key":"e_1_2_9_18_2","first-page":"486","article-title":"Biotransformation of curcumin through reduction and glucuronidation in mice","volume":"27","author":"Pan M. 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