{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:34:14Z","timestamp":1759941254416,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.2710.1818","2019HSJJ02"],"award-info":[{"award-number":["320.2710.1818","2019HSJJ02"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fujian Provincial Hospital","award":["320.2710.1818","2019HSJJ02"],"award-info":[{"award-number":["320.2710.1818","2019HSJJ02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2020,4,8]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Although surgery for hepatocellular carcinoma (HCC) complicated with inferior vena cava tumor thrombus (IVCTT) may improve survival for some patients, prognostic markers remain elusive because of its rarity. We constructed a prognostic nomogram which predicts individualized survival benefit of curative-intent surgery for HCC patients with IVCTT.<jats:italic>Methods<\/jats:italic>. According to abdominothoracic anatomy of inferior vena cava (IVC), IVCTT can be divided into 3 types: inferior diaphragmic (ID), superior diaphragmic (SD), and intracardiac type (IC). Data of 64 HCC patients with IVCTT who underwent curative-intent surgery between 2008 and 2015 in four centers in China were analyzed retrospectively. Univariate and multivariate Cox regression analyses were conducted to select variables for the construction of a prognostic nomogram. Predictive accuracy and discriminative ability were examined by concordance index (C-index) and calibration curve.<jats:italic>Results<\/jats:italic>. Of 64 patients in the IVCTT classification, 37 (57.8%) were classified as ID type, 15 (23.4%) as SD type, and 12 (18.8%) as IC type. The 1-, 2-, 3-, and 5-year disease-specific survival (DSS) rates for patients in ID, SD, and IC groups were 94.4%, 55.6%, 71.4%, and 30.0%; 27.8%, 21.4%, 7.1%, and 0%; and 8.3%, 0%, 0%, and 0%, respectively. Independent factors included in the nomogram were ECOG performance status, AFP level\u2009\u2265\u2009400\u2009<jats:italic>\u03bc<\/jats:italic>g\/L, tumor size\u2009\u2265\u200910\u2009cm, portal vein tumor thrombosis, and IVCTT classification. The C-index of the nomogram was 0.812 (95% CI 0.761\u20130.873). The calibration plot for DSS probability showed excellent agreement between the prediction by nomogram and actual observation.<jats:italic>Conclusions<\/jats:italic>. Curative-intent surgery should be carefully evaluated and suggested according to our novel IVCTT classification. We have developed a visual web-based nomogram model to predict oncological prognosis of curative-intent surgery for HCC patients with IVCTT.<\/jats:p>","DOI":"10.1155\/2020\/3264079","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T23:30:49Z","timestamp":1586388649000},"page":"1-10","source":"Crossref","is-referenced-by-count":6,"title":["Nomogram for Predicting Long-Term Survival after Synchronous Resection for Hepatocellular Carcinoma and Inferior Vena Cava Tumor Thrombosis: A Multicenter Retrospective Study"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yannan","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou 350001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, 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