{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:59:00Z","timestamp":1780635540279,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2020,1,17]]},"abstract":"<jats:p>Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare primary adenocarcinoma of nasopharynx. The immunohistochemical pattern of this tumor is similar to that of papillary thyroid carcinoma making this neoplasm a challenging diagnosis. A case of TL-LGNPPA with biphasic morphology is presented. The removed tumor from the nasopharynx exhibited a polypoid appearance. Microscopically, it was composed of papillary structures admixed with a few solid areas of spindle cells. The papillae were lined by columnar epithelium. Both the epithelium and the spindle cells were strongly positive for TTF-1 and CK19 and negative for CK5\/6, S-100, and thyroglobulin. Cellular atypia, necrosis, and high mitotic rate were absent. Ki67 was less than 2% in the neoplastic cells. No local recurrence or distant metastasis was reported after 12 months of follow-up. Caution should be taken to differentiate TL-LGPPA from other TTF-1-positive neoplasms, especially papillary thyroid carcinoma, as the prognosis for these two tumors is entirely different.<\/jats:p>","DOI":"10.1155\/2020\/3275916","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T18:31:44Z","timestamp":1579285904000},"page":"1-3","source":"Crossref","is-referenced-by-count":3,"title":["Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma with Biphasic Histology"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1770-9820","authenticated-orcid":true,"given":"Rusella","family":"Mirza","sequence":"first","affiliation":[{"name":"Department of Pathology and Translational Pathology, Louisiana State University Health Science Center, 1501 Kings Hwy, Shreveport, LA 71103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor","family":"Dela Cruz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Translational Pathology, Louisiana State University Health Science Center, 1501 Kings Hwy, Shreveport, LA 71103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo A.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of South Alabama, 307 N University Blvd, Mobile, AL 36688, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01952.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2016.1056"},{"key":"3","year":"2017"},{"key":"4","first-page":"6038","volume":"10","year":"2017","journal-title":"International Journal of Clinical Pathology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.05.020"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198812000-00005"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2016.195"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2005.04.019"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02480.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000008851"}],"container-title":["Case Reports in Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2020\/3275916.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2020\/3275916.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2020\/3275916.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T18:31:46Z","timestamp":1579285906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cripa\/2020\/3275916\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,17]]},"references-count":10,"alternative-id":["3275916","3275916"],"URL":"https:\/\/doi.org\/10.1155\/2020\/3275916","relation":{},"ISSN":["2090-6781","2090-679X"],"issn-type":[{"value":"2090-6781","type":"print"},{"value":"2090-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,17]]}}}