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Altogether, 189 PTOM patients and 200 healthy controls were genotyped of <jats:italic>IL-1\u03b1<\/jats:italic> (rs17561, rs1800587), <jats:italic>IL-1\u03b2<\/jats:italic> (rs16944, rs1143627, rs1143634, rs2853550), <jats:italic>IL-1RN<\/jats:italic> (rs4251961, rs419598, rs315951), <jats:italic>IL-4<\/jats:italic> (rs2243248, rs2243250), <jats:italic>IL-6<\/jats:italic> (rs1800795, rs1800796, rs1800797), <jats:italic>IL-8<\/jats:italic> (rs4073, rs2227306, rs2227307), <jats:italic>IL-10<\/jats:italic> (rs3024491, rs3024496, rs1800871, rs1800872, rs1800896), <jats:italic>IL-17A<\/jats:italic> (rs2275913), and <jats:italic>IL-17F<\/jats:italic> (rs763780) using the SNaPshot genotyping method. Statistical differences were observed regarding the genotype distributions of rs16944 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.049<\/mml:mn><\/mml:math>) and rs4251961 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:math>) between the patients and healthy controls. In addition, significant associations were found between rs16944 and the risk of PTOM development by dominant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext mathvariant=\"italic\">OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.854<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.017<\/mml:mn><\/mml:math>), homozygous (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mtext mathvariant=\"italic\">OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.831<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.041<\/mml:mn><\/mml:math>), and heterozygous (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mtext mathvariant=\"italic\">OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.869<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.022<\/mml:mn><\/mml:math>) models, and of rs1143627 by dominant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mtext mathvariant=\"italic\">OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.735<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.032<\/mml:mn><\/mml:math>) and homozygous (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mtext mathvariant=\"italic\">OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.839<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.040<\/mml:mn><\/mml:math>) models. Moreover, significant links were also identified between rs4251961 and the susceptibility to PTOM by dominant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mtext mathvariant=\"italic\">OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.446<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>) and heterozygous (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\"><mml:mtext mathvariant=\"italic\">OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>0.409<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>) models, and of rs1800796 by dominant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M17\"><mml:mtext mathvariant=\"italic\">OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>4.184<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M18\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.029<\/mml:mn><\/mml:math>), homozygous (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M19\"><mml:mtext mathvariant=\"italic\">OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>4.378<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M20\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.026<\/mml:mn><\/mml:math>), and heterozygous (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M21\"><mml:mtext mathvariant=\"italic\">OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>3.834<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M22\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.046<\/mml:mn><\/mml:math>) models. The present outcomes demonstrated that rs16944, rs1143627, and rs1800796 associate with increased risks, while rs4251961 links to a decreased risk of PTOM development in Chinese Han population.<\/jats:p>","DOI":"10.1155\/2020\/3278081","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T23:47:59Z","timestamp":1588722479000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["Associations between Interleukin Gene Polymorphisms and Risks of Developing Extremity Posttraumatic Osteomyelitis in Chinese Han Population"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2416-1653","authenticated-orcid":true,"given":"Nan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical 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