{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:37:28Z","timestamp":1747190248076,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2020,3,26]]},"abstract":"<jats:p>A 72-year-old man with a 10-year history of coronary heart disease started evolocumab treatment once a month after developing excess myalgia due to therapy with a 3-hydroxy-methylglutaryl CoA reductase inhibitor. No side effects such as myalgia symptoms had been reported during the first 14 months of evolocumab treatment; however, he suddenly presented with acute severe thrombocytopenia following the 14th treatment. His platelet count continued to decrease to a nadir of 1,000\/<jats:italic>\u03bc<\/jats:italic>L. His platelet-associated immunoglobulin G level had elevated to 790\u2009ng\/10<jats:sup>7<\/jats:sup>\u2009cells. He started receiving a combination of steroid therapy, high-dose immunoglobulin therapy, and platelet transfusions, but the first-line therapy was ineffective. He was subsequently treated with a thrombopoietin receptor agonist, and his platelet count recovered to 250,000\/<jats:italic>\u03bc<\/jats:italic>L.<\/jats:p>","DOI":"10.1155\/2020\/3281626","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T23:31:09Z","timestamp":1585265469000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["A Sudden Onset of Severe Thrombocytopenia While Using Evolocumab"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4633-4765","authenticated-orcid":true,"given":"Ikuo","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma, Saitama 350-0495, 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