{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:25:39Z","timestamp":1780446339849,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:00:00Z","timestamp":1585353600000},"content-version":"vor","delay-in-days":87,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Thymus atlanticus<\/jats:italic>, an endemic plant of Morocco, is traditionally used as a liniment or a drink to treat various diseases. However, there are few available scientific data regarding its biological effects. In this connection, the present study aimed to investigate the hypolipidemic and antioxidant effects of aqueous extract and polyphenol fraction of <jats:italic>Thymus atlanticus<\/jats:italic> in Syrian golden hamsters treated with Triton WR\u20101339 (triton, 20\u2009mg\/100\u2009g body weight). The hamsters orally received the extracts (400\u2009mg\/kg), and blood samples were collected after 24\u2009h of treatment to determine plasma lipid, insulin, and fasting blood glucose levels. Plasma malondialdehyde level and plasma total antioxidant (TAS) were also evaluated. The <jats:italic>T. atlanticus<\/jats:italic> extracts significantly decreased triglycerides, total cholesterol, VLDL\u2010C, and LDL\u2010C and increased HDL\u2010C when compared with the hyperlipidemic group. Both extracts suppressed the effect of the triton injection on TAS and reduced the level of plasma malondialdehyde. The extracts produced no significant change in the blood glucose level but effectively prevented the mild hyperinsulinemia induced by triton. These findings suggest that <jats:italic>T. atlanticus<\/jats:italic> may be a useful alternative treatment for the control of hyperlipidemia and its related diseases.<\/jats:p>","DOI":"10.1155\/2020\/3282596","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T23:30:38Z","timestamp":1585438238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Aqueous Extract and Polyphenol Fraction Derived from <i>Thymus atlanticus<\/i> Leaves on Acute Hyperlipidemia in the Syrian Golden Hamsters"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1343-8143","authenticated-orcid":false,"given":"Mhamed","family":"Ramchoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-7766","authenticated-orcid":false,"given":"Tarik","family":"Khouya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hicham","family":"Harnafi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souliman","family":"Amrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakib","family":"Alem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Benlyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Kasbi Chadli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El-Hassane","family":"Nazih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Ouguerram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"key":"e_1_2_9_1_2","unstructured":"Cardiovascular diseases (CVDs).https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)."},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2017.04.028"},{"key":"e_1_2_9_3_2","volume-title":"Raised Cholesterol","author":"WHO","year":"2015"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813792-5.00006-9"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnme.2012.02.005"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2018.1448921"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-018-0996-z"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2017.05.005"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.01.022"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(91)90064-k"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2017.02.002"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112475"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2015.05.011"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-019-0005-x"},{"key":"e_1_2_9_15_2","volume-title":"Biomarkers in Toxicology","author":"Gupta R. 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