{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:44:48Z","timestamp":1748843088005,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2020,1,17]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Primary hyperparathyroidism (PHPT) is a common cause of secondary osteoporosis in postmenopausal women. Th17 lymphocytes and the released cytokine IL-17A play an important role in bone metabolism. Th17 cells have been shown to be activated by PTH, and peripheral blood T cells from patients affected with PHPT express higher levels of IL-17A mRNA than controls. <jats:italic>Aim.<\/jats:italic> To investigate circulating levels of IL-17A and the ratio RANKL\/OPG, as markers of osteoclastogenesis, in 50 postmenopausal PHPT women compared with postmenopausal osteoporotic non-PHPT women (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>20<\/mml:mn><\/mml:math>). <jats:italic>Results.<\/jats:italic> Circulating levels of IL-17A were similarly detectable in most PHPT and non-PHPT osteoporotic women (12.9 (8.4-23.1) vs. 11.3 (8.3-14.3) pg\/ml, median (range interquartile), <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.759<\/mml:mn><\/mml:math>), at variance with premenopausal women where IL-17A was undetectable. In PHPT women, any significant correlations could be detected between circulating IL-17A levels and PTH levels. Nonetheless, significant negative correlations between circulating IL-17A and ionized calcium levels (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2010<\/mml:mo><mml:mn>0.294<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.047<\/mml:mn><\/mml:math>) and urine calcium excretions (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2010<\/mml:mo><mml:mn>0.300<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.045<\/mml:mn><\/mml:math>) were found. Moreover, PHPT women were characterized by positive correlations between IL-17A levels and femur neck (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.364<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.021<\/mml:mn><\/mml:math>) and total hip (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.353<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.015<\/mml:mn><\/mml:math>) <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>T<\/mml:mi><\/mml:math>-scores. Circulating IL-17A levels did not show any significant correlation with sRANKL, OPG, and sRANKL\/OPG ratio in PHPT women. <jats:italic>Conclusions<\/jats:italic>. In postmenopausal PHPT women, circulating IL-17A levels were similar to those detected in postmenopausal non-PHPT women, showing a disruption of the relationship observed in postmenopausal osteoporosis among circulating PTH, sRANKL, OPG, IL-17A, and bone demineralization in postmenopausal PHPT women. The data support an osteogenic effect of IL-17A in postmenopausal PHPT women.<\/jats:p>","DOI":"10.1155\/2020\/3417329","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T18:31:51Z","timestamp":1579285911000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5833-0780","authenticated-orcid":true,"given":"E.","family":"Dozio","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences for Health, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Passeri","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetology Service, IRCCS Istituto Ortopedico Galeazzi, Milan, 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