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While L\u2010lactic acid is an endogenous compound, D\u2010lactic acid is a harmful enantiomer. Exposure to D\u2010lactic acid can happen by various ways including contaminated food and beverages and by microbiota during some pathological states like short bowel syndrome. The exposure to D\u2010lactic acid cannot be diagnosed because the common analytical methods are not suitable for distinguishing between the two enantiomers. In this review, pathways for D\u2010lactic acid, pathological processes, and diagnostical and analytical methods are introduced followed by figures and tables. 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