{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:08Z","timestamp":1787017748666,"version":"build-2736575974"},"reference-count":218,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T00:00:00Z","timestamp":1585440000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004911","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Piau\u00ed","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004911","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PPSUS"},{"DOI":"10.13039\/501100005279","name":"Federal University of Piau\u00ed","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005279","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,3,29]]},"abstract":"<jats:p>\n                    Omeprazole (OME) is commonly used to treat gastrointestinal disorders. However, long-term use of OME can increase the risk of gastric cancer. We aimed to characterize the pharmacological effects of OME and to correlate its adverse effects and toxicogenetic risks to the genomic instability mechanisms and cancer-based on database reports. Thus, a search (till Aug 2019) was made in the PubMed, Scopus, and ScienceDirect with relevant keywords. Based on the study objective, we included 80 clinical reports, forty-six\n                    <jats:italic>in vitro<\/jats:italic>\n                    , and 76\n                    <jats:italic>in vivo<\/jats:italic>\n                    studies\n                    <jats:italic>.<\/jats:italic>\n                    While controversial, the findings suggest that long-term use of OME (5 to 40\u2009mg\/kg) can induce genomic instability. On the other hand, OME-mediated protective effects are well reported and related to proton pump blockade and anti-inflammatory activity through an increase in gastric flow, anti-inflammatory markers (COX-2 and interleukins) and antiapoptotic markers (caspases and BCL-2), glycoprotein expression, and neutrophil infiltration reduction. The reported adverse and toxic effects, especially in clinical studies, were atrophic gastritis, cobalamin deficiencies, homeostasis disorders, polyp development, hepatotoxicity, cytotoxicity, and genotoxicity. This study highlights that OME may induce genomic instability and increase the risk of certain types of cancer. Therefore, adequate precautions should be taken, especially in its long-term therapeutic strategies and self-medication practices.\n                  <\/jats:p>","DOI":"10.1155\/2020\/3457890","type":"journal-article","created":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T19:30:25Z","timestamp":1585510225000},"page":"1-21","source":"Crossref","is-referenced-by-count":20,"title":["Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6086-6469","authenticated-orcid":true,"given":"M\u00e1rcia Fernanda Correia Jardim","family":"Paz","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piau\u00ed, Teresina, PI, Brazil"},{"name":"Laboratory of Genetic Toxicity, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piau\u00ed, Teresina, PI, 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