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To investigate the mechanisms of Fuzheng Huayu (FZHY) Capsule in the treatment of hepatitis B (HBV)\u2010 associated fibrosis, HBV patients were divided into two groups, 50 cases were in the nucleotide analogues (NAs) group, while additional 50 cases were in the NAs\u2009+\u2009FZHY group. <jats:italic>Methods<\/jats:italic>. We assessed the curative effects of antifibrosis through liver function, FibroScan test, and liver biopsy and detected the ratio of lymphocyte subsets by flow cytometry. Peripheral blood lymphocyte and CD8<jats:sup>+<\/jats:sup>T, CD4<jats:sup>+<\/jats:sup>T, and natural killer cell subsets collected from patients were cocultured with LX\u20102 cells. Activation of LX\u20102 cells, production of the extracellular matrix, apoptosis, and proliferation of LX\u20102 cells were determined. Chronic liver injury models were established by ConA treatment. <jats:italic>Results<\/jats:italic>. It is evident that FZHY treatment significantly increased the percentage of NK cells, the rate of death, and apoptosis of LX\u20102 cells and decreased the FibroScan liver stiffness measurement value. The expressions of <jats:italic>\u03b1<\/jats:italic>\u2010SMA and procollagen type I mRNA in LX\u20102 cells of the FZHY treatment group as downregulated when they were cocultured with lymphocytes compared to those from the NAs group. The proliferation of LX\u20102 cells in the FZHY treatment group was inhibited compared to that in the NAs group. In a mouse model of hepatic fibrosis, PBLs and IHLs from ConA exposure plus FZHY treatment inhibited the ability of JS\u20101 cells to express <jats:italic>\u03b1<\/jats:italic>\u2010SMA. <jats:italic>Conclusions<\/jats:italic>. FZHY Capsule improved the disordered cellular immunity and postponed liver fibrosis possibly through inhibiting the interaction between lymphocyte and hepatic stellate cells.<\/jats:p>","DOI":"10.1155\/2020\/3468791","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T23:36:10Z","timestamp":1589412970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fuzheng Huayu Capsule Attenuates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate 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