{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:11:05Z","timestamp":1788401465278,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31660095"],"award-info":[{"award-number":["31660095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2014M552537XB"],"award-info":[{"award-number":["2014M552537XB"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011833","name":"Guangxi University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The flavonoid dihydromyricetin (DMY) is the main component of <jats:italic>Ampelopsis grossedentata<\/jats:italic> (Hand\u2010Mazz) W. T. Wang (AG), a daily beverage and folk medicine used in Southern China to treat jaundice hepatitis, cold fever, and sore throat. Recently, DMY and AG were shown to have a beneficial effect on lipid metabolism disorder. However, the mechanisms of how DMY and AG protect the liver during lipid metabolism disorder remain unclear. In this study, we first analyzed the chemical compounds of AG by HPLC\u2010DAD\u2010ESI\u2010IT\u2010TOF\u2010MS<jats:sup><jats:italic>n<\/jats:italic><\/jats:sup>. Of the 31 compounds detected, 29 were identified based on previous results. Then, the effects of DMY and AG on high\u2010fat diet hamster livers were studied and the metabolite levels and metabolic pathway activity of the liver were explored by <jats:sup>1<\/jats:sup>H NMR metabolomics. Compared to the high\u2010fat diet group, supplementation of AG and DMY attenuated the high\u2010fat\u2010induced increase in body weight, liver lipid deposition, serum triglycerides and total cholesterol levels, and normalized endogenous metabolite concentrations. PCA and PLS\u2010DA score plots demonstrated that while the metabolic profiles of hamsters fed a high\u2010fat diet supplemented with DMY or AG were both far from those of hamsters fed a normal diet or a high\u2010fat diet alone, they were similar to each other. Our data suggest that the underlying mechanism of the protective effect of DMY and AG might be related to an attenuation of the deleterious effect of high\u2010fat diet\u2010induced hyperlipidemia on multiple metabolic pathways including amino acid metabolism, ketone body metabolism, energy metabolism, tricarboxylic acid cycle, and enhanced fatty acid oxidation.<\/jats:p>","DOI":"10.1155\/2020\/3472578","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T23:34:00Z","timestamp":1580254440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Metabolomics of the Protective Effect of <i>Ampelopsis grossedentata<\/i> and Its Major Active Compound Dihydromyricetin on the Liver of High\u2010Fat Diet Hamster"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1959-8060","authenticated-orcid":false,"given":"Lanlan","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5263-4107","authenticated-orcid":false,"given":"Xiaosheng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4089-3611","authenticated-orcid":false,"given":"Tao","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-4796","authenticated-orcid":false,"given":"Yong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-8314","authenticated-orcid":false,"given":"Jianhua","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-239X","authenticated-orcid":false,"given":"Peigen","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"e_1_2_11_1_2","volume-title":"Quality Standard of Zhuang Medicine in Guangxi Zhuang Autonomous Region","author":"Food and Drug Administration of Guangxi Zhuang Autonomous Region","year":"2008"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2016.11.122"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i13.1398"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182830"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.02.018"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.552210136"},{"key":"e_1_2_11_7_2","first-page":"3316","article-title":"Content determination of dihydromyricetin and myricetin in leaves of Ampelopsis grossedentata by UPLC and investigation of their thermal stability","volume":"23","author":"Fan L.","year":"2012","journal-title":"China Pharmacy"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7802"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1000-565X.2011.09.025"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089021"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.007"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2017.05.003"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.02.124"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmy003"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-014-1304-4"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.42"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-014-1291-5"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01204"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.04.014"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092592"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6803943"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1489"},{"key":"e_1_2_11_23_2","first-page":"237","article-title":"Study on Ampelsis grossedentata to lower plasma lipids level","volume":"26","author":"Liu C. 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