{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:47:44Z","timestamp":1787017664947,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2017R1D1A1B03029944"],"award-info":[{"award-number":["2017R1D1A1B03029944"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","award":["2017R1D1A1B03029944"],"award-info":[{"award-number":["2017R1D1A1B03029944"]}],"id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:p>\n                    <jats:italic>Purpose<\/jats:italic>\n                    . To determine the incidence of keratoconus and to determine its possible association with common systemic diseases using a nationwide cohort.\n                    <jats:italic>Methods<\/jats:italic>\n                    . This retrospective nationwide cohort study included 1,025,340 subjects from the Korean National Health Insurance Service-National Sample Cohort database from 2004 to 2013. Estimates for incidence rates of keratoconus were identified. After 1\u2009:\u20095 matching using propensity scores, associations between keratoconus and certain systemic comorbidities were determined using multivariate logistic regression analysis.\n                    <jats:italic>Results<\/jats:italic>\n                    . The incidence during the same period was 15.1 cases per 100,000 person-years. Adjusted logistic regression analysis after propensity score matching revealed significant associations between keratoconus and allergic rhinitis (odds ratio (OR): 1.86; 95% confidence interval (CI): 1.63\u20132.13;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>&lt;<\/mml:mo>\n                        <mml:mn>0.001<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), asthma (OR: 1.20; 95% CI: 1.06\u20131.36;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>&lt;<\/mml:mo>\n                        <mml:mn>0.001<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), atopic dermatitis (OR: 1.33; 95% CI: 1.13\u20131.56;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>&lt;<\/mml:mo>\n                        <mml:mn>0.001<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), and diabetes mellitus (DM) (OR: 1.35; 95% CI: 1.15\u20131.58;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mrow>\n                        <mml:mi>p<\/mml:mi>\n                        <mml:mo>&lt;<\/mml:mo>\n                        <mml:mn>0.001<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Estimates of the incidence of keratoconus may help in the planning of eye-care policies, and the results of this study determined the associations between allergic diseases and keratoconus. Conflicting results regarding the association between keratoconus and DM should be further evaluated.\n                  <\/jats:p>","DOI":"10.1155\/2020\/3493614","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T19:30:57Z","timestamp":1585769457000},"page":"1-6","source":"Crossref","is-referenced-by-count":22,"title":["Incidence of Keratoconus and Its Association with Systemic Comorbid Conditions: A Nationwide Cohort Study from South Korea"],"prefix":"10.1155","volume":"2020","author":[{"given":"Jong Youn","family":"Moon","sequence":"first","affiliation":[{"name":"Institute of Health Services Research, Yonsei University, College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Soonchunhyang University Hospital Bucheon, Bucheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Hyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Soonchunhyang University, College of Medicine, Cheonan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-5398","authenticated-orcid":true,"given":"Eun-Cheol","family":"Park","sequence":"additional","affiliation":[{"name":"Institute of Health Services Research, Yonsei University, College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6383-4673","authenticated-orcid":true,"given":"Si Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Soonchunhyang University Hospital Bucheon, Bucheon, Republic of 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