{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:25:06Z","timestamp":1768296306937,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81704166"],"award-info":[{"award-number":["81704166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973936"],"award-info":[{"award-number":["81973936"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473784"],"award-info":[{"award-number":["81473784"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Acupuncture strongly alleviates gastrointestinal symptoms and especially promotes gastrointestinal motility. However, the mechanism underlying these processes is poorly understood. This study was designed to examine the effect of electroacupuncture (EA) at gastric back\u2010shu (BL21) and front\u2010mu (RN12) acupoints on gastric motility in functional dyspepsia (FD) rats and to investigate the mechanisms of its effects on the glutamatergic system in the hippocampus. We found that EA at RN12 or BL21 enhanced gastric motility in FD rats, whereas EA at the combination of RN12 and BL21 showed an additional effect. Microdialysis combined with HPLC showed that EA reduced the glutamate content in the hippocampus, and the NMDAR\u2010NO\u2010cGMP signalling pathway was downregulated, as determined by Western blot assays, in FD rats. In addition, we found that decreased gastric motility was significantly restored by the hippocampal infusion of an NMDAR, nNOS, or sGC antagonist. Interestingly, EA had no further effects on gastric motility in the presence of these antagonists in FD rats. Taken together, these results suggest that the hippocampal glutamatergic system is involved in the regulation of gastric motility by EA at RN12 and BL21.<\/jats:p>","DOI":"10.1155\/2020\/3524641","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T23:35:31Z","timestamp":1583883331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Acupuncture at Gastric Back\u2010Shu and Front\u2010Mu Acupoints Enhances Gastric Motility via the Inhibition of the Glutamatergic System in the Hippocampus"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-437X","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-0370","authenticated-orcid":false,"given":"Guo-Ming","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1159\/000484029"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000393"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.81"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13393"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2014.0400"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617724061"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i27.8304"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i48.13480"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/291764"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216654228"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130055"},{"key":"e_1_2_9_12_2","first-page":"363","article-title":"Progress on the relationship between the regulation of gastrointestinal system function by acupuncture and central nuclei","volume":"42","author":"Bu F. Y.","year":"2017","journal-title":"Zhen Ci Yan Jiu (Acupuncture Research)"},{"key":"e_1_2_9_13_2","first-page":"322","article-title":"Effect of electroacupuncture on expression of ghrelin and mRNA expression of its receptor in functional dyspesia rats","volume":"36","author":"Zhou L.","year":"2016","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi-Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2014.10.001"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1540\/jsmr.54.91"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2016.04.001"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00395.2017"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.08.010"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibror.2018.11.004"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14043"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.11.008"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.13.7557022"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/336385a0"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.03.012"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.13703\/j.0255-2930.2018.03.016"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.00795.x"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0468-2"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.5056\/jnm16173"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.13702\/j.1000-0607.180571"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.13702\/j.1000-0607.170299"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/918392"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7457485"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i19.2315"},{"key":"e_1_2_9_34_2","first-page":"1052","article-title":"Effects and mechanisms of L-glutamate microinjected into nucleus ambiguus on gastric motility in rats","volume":"123","author":"Sun H. Z.","year":"2019","journal-title":"Chinese Medical Journal (Engl)"},{"key":"e_1_2_9_35_2","first-page":"196","article-title":"The association of hippocampal glutamate with depression and the effects on gastric mobility","volume":"25","author":"Wang M. H.","year":"2009","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi-Chinese Journal of Applied Physiology"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2013-0413"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363090-00003"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.13703\/j.0255-2930.2019.05.012"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12532"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000449"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.04.028"},{"key":"e_1_2_9_42_2","first-page":"1","volume-title":"Advances in Pharmacology","author":"Monica F. Z.","year":"2016"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/3524641.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/3524641.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/3524641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T09:09:11Z","timestamp":1723021751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/3524641"}},"subtitle":[],"editor":[{"given":"Michel M.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/3524641"],"URL":"https:\/\/doi.org\/10.1155\/2020\/3524641","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3524641"}}