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It is successfully applied in the treatment of some forms of localized pain syndromes and other local clinical conditions. It could be suggested when a systemic drug-sparing effect is useful, when other therapies have failed (or cannot be used), and when it can synergize with other pharmacological or nonpharmacological therapies. Despite the lack of randomized clinical trials in some fields of application, a general consensus is also reached in nonpharmacological mechanism of action, the technique execution modalities, the scientific rationale to apply it in some indications, and the usefulness of the informed consent. The Italian Mesotherapy Society proposes this position paper to apply intradermal therapy based on scientific evidence and no longer on personal bias.<\/jats:p>","DOI":"10.1155\/2020\/3542848","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T23:30:51Z","timestamp":1588375851000},"page":"1-9","source":"Crossref","is-referenced-by-count":50,"title":["Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9515-3549","authenticated-orcid":true,"given":"Massimo","family":"Mammucari","sequence":"first","affiliation":[{"name":"Primary Care Unit ASL RM 1, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Maggiori","sequence":"additional","affiliation":[{"name":"Primary Care Unit ASL RM 1, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Russo","sequence":"additional","affiliation":[{"name":"\u201cSan Marco\u201d Hospice and Palliative Care, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Giorgio","sequence":"additional","affiliation":[{"name":"Rehabilitation Unit, F Pirinei Hospital, Altamura, BA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpaolo","family":"Ronconi","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Unit, IRCCS, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola E","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Unit, IRCCS, Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Canzona","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico Dell\u2019Immacolata, IRCCS Foundation, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Antonaci","sequence":"additional","affiliation":[{"name":"Primary Care Unit ASL RM 1, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartolomeo","family":"Violo","sequence":"additional","affiliation":[{"name":"Pain Therapy Unit, S. 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