{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:32:04Z","timestamp":1765888324286,"version":"3.37.3"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mount Sinai Hospital"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canadian Pain Network"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2020,4,28]]},"abstract":"<jats:p>Ehlers\u2013Danlos syndrome (EDS) is a connective tissue disorder characterized by joint hypermobility and skin extensibility and is often accompanied by chronic pain. Rhythmic sensory stimulation (RSS) can be defined as the stimulation of the senses in a periodic manner within a range of low frequencies. Music plus sound delivered through a vibroacoustic device is a form of RSS and has demonstrated utility in managing pain. In this current study, we conducted an open-label pilot study of 15 patients with hypermobile EDS using RSS as the intervention. Posttreatment improvements were seen in 11 of the 15 patients (73%), whereas 3 of the 15 patients (20%) experienced worse outcomes. Of the 14 patients that completed the experiment, 6 participants (43%) were classified as \u201cresponders\u201d to the device while 8 participants (57%) were classified as \u201cnonresponders.\u201d Responders demonstrated significant improvements in pain interference (51.5\u2009\u00b1\u200916 preintervention vs. 43.5\u2009\u00b1\u200916.4 postintervention BPI score) and depression symptoms (34.0\u2009\u00b1\u200915.9 preintervention vs. 26.8\u2009\u00b1\u200912.1 postintervention CESD score). Poststudy interviews confirm the improvements of pain interference, mood, and bowel symptoms. Furthermore, analysis of medical conditions within the responder group indicates that the presence of depression, anxiety, irritable bowel syndrome, and fibromyalgia may indicate a greater likelihood for patients to benefit with vibroacoustic applications. These results indicate a possible potential for RSS, delivered using a vibroacoustic device, in managing pain-related symptoms. Further research is necessary to elucidate the exact mechanism behind the physiological benefits of RSS.<\/jats:p>","DOI":"10.1155\/2020\/3586767","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T23:30:56Z","timestamp":1588116656000},"page":"1-10","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Rhythmic Sensory Stimulation on Ehlers\u2013Danlos Syndrome: A Pilot Study"],"prefix":"10.1155","volume":"2020","author":[{"given":"Veronica","family":"Vuong","sequence":"first","affiliation":[{"name":"Faculty of Music, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Mosabbir","sequence":"additional","affiliation":[{"name":"Faculty of Music, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Paneduro","sequence":"additional","affiliation":[{"name":"Wasser Pain Management 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