{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:13:38Z","timestamp":1778937218047,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lianyungang City Science and Technology Plan Funding Project of Jiangsu province","award":["SH1601"],"award-info":[{"award-number":["SH1601"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To identify the clinical correlations between plasma growth differentiation factor\u201015 (GDF\u201015), skeletal muscle function, and acute muscle wasting in ICU patients with mechanical ventilation. In addition, to investigate its diagnostic value for ICU\u2010acquired weakness (ICU\u2010AW) and its predictive value for 90\u2010day survival in mechanically ventilated patients. <jats:italic>Methods<\/jats:italic>. 95 patients with acute respiratory failure, who required mechanical ventilation therapy, were randomly selected among hospitalized patients from June 2017 to January 2019. The plasma GDF\u201015 level was detected by ELISA, the rectus femoris cross\u2010sectional area (RFcsa) was measured by ultrasound, and the patient\u2019s muscle strength was assessed using the British Medical Research Council (MRC) muscle strength score on day 1, day 4, and day 7. Patients were divided into an ICU\u2010AW group and a non\u2010ICU\u2010AW group according to their MRC\u2010score on the 7th day. The differences in plasma GDF\u201015 level, MRC\u2010score, and RFcsa between the two groups were compared on the 1st, 4th, and 7th day after being admitted to the ICU. Then, the correlations between plasma GDF\u201015 level, RFcsa loss, and MRC\u2010score on day 7 were investigated. The receiver operating characteristic curve (ROC) was used to analyze the plasma GDF\u201015 level, RFcsa loss, and % decrease in RFcsa on the 7th day to the diagnosis of ICU\u2010AW in mechanically ventilated patients. Moreover, the predictive value of GDF\u201015 on the 90\u2010day survival status of patients was assessed using patient survival curves. <jats:italic>Results<\/jats:italic>. Based on whether the 7th day MRC\u2010score was &lt;48, 50 cases were included in the ICU\u2010AW group and 45 cases in the non\u2010ICU\u2010AW group. The length of mechanical ventilation, ICU length of stay, and hospital length of stay were significantly longer in the ICU\u2010AW group than in the non\u2010ICU\u2010AW group (all <jats:italic>P<\/jats:italic> &lt; 0.05), while the other baseline indicators were not statistically significant between the two groups. As the treatment time increased, the plasma GDF\u201015 level was significantly increased, the ICU\u2010AW group demonstrated a significant decreasing trend in the MRC\u2010score and RFcsa, while no significant changes were found in the non\u2010ICU\u2010AW group. In the ICU\u2010AW group, the plasma GDF\u201015 level was significantly higher than that in the non\u2010ICU\u2010AW group, while the RFcsa and the MRC\u2010score were significantly lower than those in the non\u2010ICU\u2010AW group (GDF\u201015 (pg\/ml): 2542.44\u2009\u00b1\u2009629.38 vs. 1542.86\u2009\u00b1\u2009502.86; RFcsa (cm<jats:sup>2<\/jats:sup>): 2.04\u2009\u00b1\u20090.64 vs. 2.34\u2009\u00b1\u20090.61; MRC\u2010score: 41.22\u2009\u00b1\u20093.42 vs. 51.42\u2009\u00b1\u20092.72, all <jats:italic>P<\/jats:italic> &lt; 0.001). The plasma GDF\u201015 level was significantly negatively correlated with the MRC\u2010score (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.60), while it was significantly positively correlated with the RFcsa loss (<jats:italic>r<\/jats:italic>\u2009=\u20090.18) and the % decrease in RFcsa (<jats:italic>r<\/jats:italic>\u2009=\u20090.16). Moreover, the RFcsa loss was significantly negatively correlated with the MRC\u2010score (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.27) (all <jats:italic>P<\/jats:italic> &lt; 0.001). The ROC curve analysis showed that plasma GDF\u201015 level, RFcsa loss, and % decrease in RFcsa on day 7 had predictive value for ICU\u2010AW diagnosis in mechanically ventilated patients. More specifically, the area under the ROC curve (AUC) of GDF\u201015 was 0.904, the AUC of RFcsa loss was 0.873, and the AUC of % decrease in RFcsa was 0.886 (all <jats:italic>P<\/jats:italic> &lt; 0.001). The 90\u2010day survival curve demonstrated that the survival rate of the high plasma GDF\u201015 level group was 54.00%, while that of the low plasma GDF\u201015 level group was 75.56%. The difference between the two groups was statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.05). <jats:italic>Conclusion<\/jats:italic>. The plasma GDF\u201015 concentration level was significantly associated with skeletal muscle function and muscle wasting on day 7 in ICU patients with mechanical ventilation. Therefore, it can be concluded that the plasma GDF\u201015 level on the 7th day has a high diagnostic yield for ICU\u2010acquired muscle weakness, and it can predict the 90\u2010day survival status of ICU mechanically ventilated patients.<\/jats:p>","DOI":"10.1155\/2020\/3630568","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T23:31:00Z","timestamp":1581463860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Utility of Plasma GDF\u201015 for Diagnosis and Prognosis Assessment of ICU\u2010Acquired Weakness in Mechanically Ventilated Patients: Prospective Observational 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