{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T15:17:57Z","timestamp":1767453477795,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2020,4,10]]},"abstract":"<jats:p>Epstein\u2013Barr virus infection is most commonly asymptomatic in the acute setting, where the end result of infection is the adoption of a viral latency phenotype. The virus can reactivate later in life leading to the abnormal proliferation of the infected B, T, or NK cells. Hereby, we report a 71-year-old female with seronegative rheumatoid arthritis who presented with massive splenomegaly, pancytopenia, and positivization of antibodies against double-stranded deoxyribonucleic acid (dsDNA) after initiation of the anti-tumor necrosis factor (TNF) golimumab. The diagnosis of EBV-associated lymphoproliferative disorder (LPD) was demonstrated by elevation of the plasmatic EBV viral load. Withdrawal of the anti-TNF and treatment with the anti-CD20 antibody rituximab were able to revert the clinical abnormalities. EBV-associated LPDs are described after initiation of other anti-TNF agents, such as infliximab, but no reports of golimumab-associated EBV LPD are found in the literature. The mechanisms for this occurrence are not clear, but these are known to involve expression of a panel of viral proteins specific to the viral latency phenotypes.<\/jats:p>","DOI":"10.1155\/2020\/3641813","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T23:33:33Z","timestamp":1586561613000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Reactivation of Epstein\u2013Barr Virus Presenting as Massive Splenomegaly after Initiation of Golimumab Treatment"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-425X","authenticated-orcid":true,"given":"Anthony J.","family":"Febres-Aldana","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Febres-Aldana","sequence":"additional","affiliation":[{"name":"Arkadi M. Rywlin Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Dvir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gliceida","family":"Galarza-Fortuna","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Medina","sequence":"additional","affiliation":[{"name":"Arkadi M. Rywlin Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"},{"name":"Herbert Wertheim College of Medicine, Florida International University, Miami 33199, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vathany","family":"Sriganeshan","sequence":"additional","affiliation":[{"name":"Arkadi M. Rywlin Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"},{"name":"Herbert Wertheim College of Medicine, Florida International University, Miami 33199, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"first-page":"127","volume-title":"Epstein-Barr virus","year":"2015","key":"1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.05.020"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02213.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.102"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04112.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12525"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/530568"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31407"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.085852"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/art.22579"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.12.001"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.11.3909"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12116"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1186\/s12895-015-0025-y"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20131"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2005.01.008"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/art.10933"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2010.04.014"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/ar2708"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00062"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014488"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2014.09.014"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/art.10739"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0728-5"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00334"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00081"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2020\/3641813.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2020\/3641813.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2020\/3641813.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T23:33:35Z","timestamp":1586561615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2020\/3641813\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,10]]},"references-count":27,"alternative-id":["3641813","3641813"],"URL":"https:\/\/doi.org\/10.1155\/2020\/3641813","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2020,4,10]]}}}