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We hypothesize that T-type calcium channel may be a potential therapeutic target for acute lung injury (ALI). In this study, the pharmacological activity of mibefradil (a classical T-type calcium channel inhibitor) was assessed in a mouse model of lipopolysaccharide- (LPS-) induced ALI. In LPS challenged mice, mibefradil (20 and 40\u2009mg\/kg) dramatically decreased the total cell number, as well as the productions of TNF-\u03b1 and IL-6 in bronchoalveolar lavage fluid (BALF). Mibefradil also suppressed total protein concentration in BALF, attenuated Evans blue extravasation, MPO activity, and NF-\u03baB activation in lung tissue. Furthermore, flunarizine, a widely prescripted antimigraine agent with potent inhibition on T-type channel, was also found to protect mice against lung injury. These data demonstrated that T-type calcium channel inhibitors may be beneficial for treating acute lung injury. The important role of T-type calcium channel in the acute lung injury is encouraged to be further investigated.<\/jats:p>","DOI":"10.1155\/2020\/3691701","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T17:35:39Z","timestamp":1605029739000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3925-5943","authenticated-orcid":true,"given":"Limei","family":"Wan","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, 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