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In complexes <jats:bold>1\u20133<\/jats:bold>, the corresponding nitrogen-containing heterocycle acts as a bridging ligand between two Ag(I) ions. <jats:italic>In vitro<\/jats:italic> antimicrobial activity of these complexes, along with the ligands used for their synthesis, was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and fungi. The silver(I) complexes <jats:bold>1\u20133<\/jats:bold> showed selectivity towards <jats:italic>Candida<\/jats:italic> spp. and Gram-negative <jats:italic>Escherichia coli<\/jats:italic> in comparison to the other investigated bacterial strains, effectively inhibiting the growth of four different <jats:italic>Candida<\/jats:italic> species with minimal inhibitory concentrations (MICs) between 2.5 and 25\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL and the growth of <jats:italic>E. coli<\/jats:italic>, with MIC value being 12.5\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. Importantly, complex <jats:bold>2<\/jats:bold> significantly reduced <jats:italic>C. albicans<\/jats:italic> filamentation, an essential process for its pathogenesis. Antiproliferative effect on the normal human lung fibroblast cell line MRC-5 was also evaluated with the aim of determining the therapeutic potential of the complexes <jats:bold>1\u20133<\/jats:bold>. The interactions of these complexes with calf thymus DNA (ctDNA) and bovine serum albumin (BSA) were studied to evaluate their binding activities towards these biomolecules for possible insights on their mode of action.<\/jats:p>","DOI":"10.1155\/2020\/3812050","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T23:31:32Z","timestamp":1586907092000},"page":"1-12","source":"Crossref","is-referenced-by-count":15,"title":["Antimicrobial Activity and DNA\/BSA Binding Affinity of Polynuclear Silver(I) Complexes with 1,2-Bis(4-pyridyl)ethane\/ethene as Bridging Ligands"],"prefix":"10.1155","volume":"2020","author":[{"given":"Sonja \u017d.","family":"\u0110uri\u0107","sequence":"first","affiliation":[{"name":"University of Kragujevac, Faculty of Science, Department of Chemistry, R. 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Domanovi\u0107a 12, 34000 Kragujevac, Serbia"},{"name":"University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cviji\u0107a bb, 34000 Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Nikodinovic-Runic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-8611","authenticated-orcid":true,"given":"Biljana \u0110.","family":"Gli\u0161i\u0107","sequence":"additional","affiliation":[{"name":"University of Kragujevac, Faculty of Science, Department of Chemistry, R. 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