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STHJ is commonly used to treat diseases caused by low immune function, for example, Sj\u00f6gren\u2019s syndrome (SS). The primary objective of this study was to assess the immunopotentiating effect of STHJ using an immunosuppressive mouse model receiving cyclophosphamide (CTX). Following CTX treatment, STHJ was administered by oral gavage for 30 consecutive days. The percentage of specific lymphocyte subpopulations in the spleen was measured by flow cytometry. Levels of inflammatory factors in serum were detected by enzyme\u2010linked immunosorbent assays (ELISAs). The administration of STHJ significantly elevated thymus and spleen indices, increased B cell and natural killer (NK) cell activities, and decreased CD8<jats:sup>+<\/jats:sup> T, CD8<jats:sup>+<\/jats:sup>CD122<jats:sup>+<\/jats:sup> T, NKT, and <jats:italic>\u03b3\u03b4<\/jats:italic>T cell activities in the CTX\u2010treated mice. In addition, STHJ upregulated the expression of interleukin\u2010 (IL\u2010) 2, IL\u20106, and tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>) and downregulated IL\u201010 expression in CTX\u2010treated mice. In conclusion, STHJ effectively remitted CTX\u2010induced immunosuppression by modulating the balance of lymphocyte subsets and cytokines. Our results suggest STHJ treatment could be used as an effective therapeutic approach to improve immune function in patients with low immunity.<\/jats:p>","DOI":"10.1155\/2020\/3849847","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T23:31:03Z","timestamp":1579822263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide\u2010Treated Mice"],"prefix":"10.1155","volume":"2020","author":[{"given":"Kai-Jian","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Wu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-8457","authenticated-orcid":false,"given":"Qing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5000-7890","authenticated-orcid":false,"given":"Ting-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2017.02.014"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.04.011"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.12.029"},{"key":"e_1_2_12_4_2","first-page":"29","article-title":"Quality assay of Pseudostellaria heterophylla collected from different regions","volume":"5","author":"Qin M. 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