{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:10:46Z","timestamp":1772781046293,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2020,1,3]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. The current use of lipid lowering therapies and the eligibility for proprotein convertase subtilisin\/kexin-9 (PCSK9) inhibitors of patients surviving a myocardial infarction (MI) is poorly known. <jats:italic>Methods<\/jats:italic>. Using the data from two contemporary, nationwide, prospective, real-world registries of patients with stable coronary artery disease, we sought to describe the lipid lowering therapies prescribed by cardiologists in patients with a prior MI and the resulting eligibility for PCSK9 inhibitors according to the European Society of Cardiology (ESC)\/European Atherosclerosis Society (EAS) and the Italian regulatory agency (Agenzia Italiana del Farmaco; AIFA) criteria. The study cohort was stratified according to the following low-density lipoprotein cholesterol (LDL-C) levels at the time of enrolment: &lt;70\u2009mg\/dl; 70\u201399\u2009mg\/dl and \u2265100\u2009mg\/dl. <jats:italic>Results<\/jats:italic>. Among the 3074 post-MI patients with LDL-C levels available, a target level of LDL-C\u2009&lt;\u200970\u2009mg\/dl was present in 1186 (38.6%), while 1150 (37.4%) had LDL-C levels ranging from 70 to 99\u2009mg\/dl and the remaining 738 (24.0%) an LDL-C\u2009\u2265\u2009100\u2009mg\/dl. A statin was prescribed more frequently in post-MI patients with LDL-C levels &lt;70\u2009mg\/dl (97.1%) compared to the other LDL-C groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:mrow><\/mml:math>). A low dose of statin was prescribed in 9.3%, while a high dose in 61.4% of patients. Statin plus ezetimibe association therapy was used in less than 18% of cases. In the overall cohort, 293 (9.8%) and 450 (22.2%) resulted eligible for PCSK9 inhibitors, according to ESC\/EAS and AIFA criteria, respectively. <jats:italic>Conclusions<\/jats:italic>. Post-MI patients are undertreated with conventional lipid lowering therapies. A minority of post-MI patients would be eligible to PCSK9 inhibitors according to ESC\/EAS guidelines and Italian regulatory agency criteria.<\/jats:p>","DOI":"10.1155\/2020\/3856242","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T18:31:01Z","timestamp":1578076261000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Lipid Lowering Treatment and Eligibility for PCSK9 Inhibition in Post-Myocardial Infarction Patients in Italy: Insights from Two Contemporary Nationwide Registries"],"prefix":"10.1155","volume":"2020","author":[{"given":"Furio","family":"Colivicchi","sequence":"first","affiliation":[{"name":"Division of Cardiology, S. Filippo Neri Hospital, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Massimo Gulizia","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Garibaldi-Nesima Hospital, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Arca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, Sapienza University of Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier","family":"Luigi Temporelli","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Istituti Clinici Scientifici Maugeri, IRCCS, Veruno (Novara), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"Gonzini","sequence":"additional","affiliation":[{"name":"ANMCO Research Center, Fondazione per il Tuo cuore, Firenze, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Venturelli","sequence":"additional","affiliation":[{"name":"Division of Cardiology, S. Pertini Hospital, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuccia","family":"Morici","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Niguarda Ca\u2019Grande Hospital, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1241-6487","authenticated-orcid":true,"given":"Ciro","family":"Indolfi","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Universit\u00e0 degli Studi Magna Graecia, Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Augusto Murri Hospital, Fermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-1272","authenticated-orcid":true,"given":"Leonardo","family":"De Luca","sequence":"additional","affiliation":[{"name":"Division of Cardiology, S. 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