{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:24:36Z","timestamp":1779927876104,"version":"3.53.1"},"reference-count":98,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":344,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Project in Science and Technology of Henan Province","award":["182102410083"],"award-info":[{"award-number":["182102410083"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Hepatitis B is a global infectious disease, seriously endangering human health. Currently, there are mainly interferons and nucleoside analogues treatment of hepatitis B in the clinic, which have certain therapeutic effects on hepatitis B, but their side effects and drug resistance are increasingly prominent. Therefore, it is urgently needed to discover and develop new anti\u2010HBV drugs, especially natural products, which have novel, high efficiency, and low toxicity anti\u2010HBV compounds with novel antiviral mechanisms. In this manuscript, the natural products (polysaccharides and 165 compounds) with the activity of antihepatitis B virus are discussed according to their chemical classes, including 14 phenylpropanoids, 8 flavonoids,12 xanthones, 13 anthroquinones, 47 terpenoids, 6 alkaloids, 15 enediynes, 11 aromatics, 18 phenylalanine dipeptides compounds, and 13 others. In addition, the anti\u2010HBV mechanism and targets of natural product were also discussed. The aim of this review is to report new discoveries about anti\u2010HBV natural products and to provide reference for researchers.<\/jats:p>","DOI":"10.1155\/2020\/3972390","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T22:35:07Z","timestamp":1607639707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Natural Products: Review for Their Effects of Anti\u2010HBV"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9345-5631","authenticated-orcid":false,"given":"Xuqiang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1583-9741","authenticated-orcid":false,"given":"Changyang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0053-1923","authenticated-orcid":false,"given":"Zhenhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-6249","authenticated-orcid":false,"given":"Wenyi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2008.5"},{"key":"e_1_2_8_2_2","first-page":"545","article-title":"Hepatitis B today","volume":"54","author":"Safioleas M.","year":"2007","journal-title":"Hepato-Gastroenterology"},{"key":"e_1_2_8_3_2","unstructured":"World Health Organisation Hepatitis B factsheet No.204 2014 https:\/\/www.who.int\/Mediacentre\/factsheets\/fs204\/en\/1."},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0016-5_22"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2217\/17460794.4.1.55"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570193X11310030004"},{"key":"e_1_2_8_7_2","first-page":"2302","article-title":"Research advances in anti-hepatitis B virus drugs","volume":"35","author":"Cai M. 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