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The increased risk and poor survival outcome of cervical adenocarcinoma (CAC) demand for effective early diagnostic biomarkers that can predict the disease progression and outcome. The purpose of this study was to investigate the value of methylation status of <jats:italic>SOX1<\/jats:italic> and <jats:italic>PAX1<\/jats:italic> in the detection and prognosis of CAC. <jats:italic>Methods<\/jats:italic>. We performed a quantitative methylation\u2010specific polymerase chain reaction in 205 cervical paraffin\u2010embedded specimens (175 CACs, 30 noncancer cervical tissues). Overall and progression\u2010free survival (OS and PFS, respectively) rates were calculated and compared using the Kaplan\u2010Meier method. The prognostic value of <jats:italic>SOX1<jats:sup>m<\/jats:sup><\/jats:italic> and <jats:italic>PAX1<jats:sup>m<\/jats:sup><\/jats:italic> on CAC patients was assessed by the Cox regression model. A mathematical formula combining <jats:italic>SOX1<jats:sup>m<\/jats:sup><\/jats:italic>, <jats:italic>PAX1<jats:sup>m<\/jats:sup><\/jats:italic>, and age was constructed for survival prediction. <jats:italic>Results<\/jats:italic>. The methylation status of <jats:italic>SOX1<\/jats:italic> and <jats:italic>PAX1<\/jats:italic> was higher in CAC tissues than in noncancer cervical tissues. In addition, <jats:italic>SOX1<jats:sup>m<\/jats:sup><\/jats:italic>\u2010positive CAC patients showed a higher 5\u2010year OS rate than <jats:italic>SOX1<jats:sup>m<\/jats:sup><\/jats:italic>\u2010negative patients. In CAC patients with smaller tumor size (&lt;4\u2009cm), the <jats:italic>PAX1<jats:sup>m<\/jats:sup><\/jats:italic>\u2010positive group showed a higher 5\u2010year PFS rate than the <jats:italic>PAX1<jats:sup>m<\/jats:sup><\/jats:italic>\u2010negative group. In the algorithm combining <jats:italic>SOX1<jats:sup>m<\/jats:sup><\/jats:italic>, <jats:italic>PAX1<jats:sup>m<\/jats:sup><\/jats:italic>, and age, the low\u2010risk group showed a better 5\u2010year OS and PFS rate than the high\u2010risk group. <jats:italic>Conclusion<\/jats:italic>. <jats:italic>SOX1<\/jats:italic> and <jats:italic>PAX1<\/jats:italic> methylation levels are higher in CAC than in normal cervical tissues and are potential biomarkers for monitoring CAC prognosis.<\/jats:p>","DOI":"10.1155\/2020\/3981529","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T02:58:56Z","timestamp":1607482736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>SOX1<\/i> and <i>PAX1<\/i> Are Hypermethylated in Cervical Adenocarcinoma and Associated with Better Prognosis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Zitong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-3206","authenticated-orcid":false,"given":"Na-Yi Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7286-5335","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.09.040"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.971"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(89)90524-6"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900601)65:11<2507::AID-CNCR2820651120>3.0.CO;2-9"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1265"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.1999.0923"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.10.004"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00854.x"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000780"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2016.02.11"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1045"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp220"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90418-9"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg816"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6349(10)72251-5"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.02.005"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.07.111"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2017_513"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.08.065"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12719"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.10.018"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200987"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.1.23"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(05)80177-6"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.4161\/epi.29025"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.06.024"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000155"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23957"},{"key":"e_1_2_11_30_2","article-title":"PAX1 methylation as a potential biomarker for cervical cancer screening","volume":"24","author":"Kan Y. 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