{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:33:14Z","timestamp":1773779594188,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Project Foundation of Shenyang","award":["19-112-4-005"],"award-info":[{"award-number":["19-112-4-005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2020,9,24]]},"abstract":"<jats:p><jats:italic>Background and Aim<\/jats:italic>. Liver cirrhosis is often accompanied by insidious cardiac dysfunction. This retrospective cross-sectional study is aimed at exploring the correlation between serum cardiac markers and decompensating events in liver cirrhosis.<jats:italic>Methods<\/jats:italic>. Cirrhotic patients who were consecutively hospitalized between January 2016 and March 2019 were screened. Serum cardiac biomarkers at admission, including N-Terminal pro-B-type natriuretic peptide (NT-pro BNP), high-sensitivity cardiac troponin T (hs-cTnT), creatine kinase (CK), creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH), were collected. Acute decompensating events at admission, primarily including ascites, acute gastrointestinal hemorrhage, and acute-on-chronic liver failure (ACLF), were recorded.<jats:italic>Results<\/jats:italic>. The NT-pro BNP level was significantly higher in cirrhotic patients with acute decompensating events than in those without any decompensating events (median: 140.75\u2009pg\/mL versus 41.86\u2009pg\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). The NT-pro BNP level significantly correlated with ascites, acute gastrointestinal hemorrhage, and ACLF. The hs-cTnT level was significantly higher in cirrhotic patients with acute decompensating events than in those without decompensating events (median: 0.008\u2009ng\/mL versus 0.006\u2009ng\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:math>). The hs-cTnT level significantly correlated with acute gastrointestinal hemorrhage, but not ascites or ACLF. LDH (185.0\u2009U\/L versus 173.5\u2009U\/L,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.281<\/mml:mn><\/mml:math>), CK (71\u2009U\/L versus 84\u2009U\/L,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.157<\/mml:mn><\/mml:math>), and CK-MB (29.5\u2009U\/L versus 33.0\u2009U\/L,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.604<\/mml:mn><\/mml:math>) levels were not significantly different between cirrhotic patients with and without acute decompensating events.<jats:italic>Conclusion<\/jats:italic>. The elevated NT-pro BNP level seems to be closely related to the development of acute decompensating events in liver cirrhosis.<\/jats:p>","DOI":"10.1155\/2020\/4019289","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T23:31:55Z","timestamp":1600990315000},"page":"1-15","source":"Crossref","is-referenced-by-count":7,"title":["Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Miaomiao","family":"Li","sequence":"first","affiliation":[{"name":"Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Northern Theater Command (Formerly General Hospital of Shenyang Military Area), Shenyang, China"},{"name":"Department of Clinical Laboratory, The First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeqi","family":"Guo","sequence":"additional","affiliation":[{"name":"Liver 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