{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:17:33Z","timestamp":1771654653079,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20190108KJ"],"award-info":[{"award-number":["JJKH20190108KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20180676KJ"],"award-info":[{"award-number":["JJKH20180676KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["20191102027YY"],"award-info":[{"award-number":["20191102027YY"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["2018YFE0107800"],"award-info":[{"award-number":["2018YFE0107800"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20190108KJ"],"award-info":[{"award-number":["JJKH20190108KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20180676KJ"],"award-info":[{"award-number":["JJKH20180676KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["20191102027YY"],"award-info":[{"award-number":["20191102027YY"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["2018YFE0107800"],"award-info":[{"award-number":["2018YFE0107800"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Health Project in Jilin Province, China","award":["JJKH20190108KJ"],"award-info":[{"award-number":["JJKH20190108KJ"]}]},{"name":"Medical Health Project in Jilin Province, China","award":["JJKH20180676KJ"],"award-info":[{"award-number":["JJKH20180676KJ"]}]},{"name":"Medical Health Project in Jilin Province, China","award":["20191102027YY"],"award-info":[{"award-number":["20191102027YY"]}]},{"name":"Medical Health Project in Jilin Province, China","award":["2018YFE0107800"],"award-info":[{"award-number":["2018YFE0107800"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["JJKH20190108KJ"],"award-info":[{"award-number":["JJKH20190108KJ"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["JJKH20180676KJ"],"award-info":[{"award-number":["JJKH20180676KJ"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["20191102027YY"],"award-info":[{"award-number":["20191102027YY"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2018YFE0107800"],"award-info":[{"award-number":["2018YFE0107800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,1,8]]},"abstract":"<jats:p><jats:italic>Aronia melanocarpa<\/jats:italic>(AM), which is rich in anthocyanins and procyanidins, has been reported to exert antioxidative and anti-inflammatory effects. This study aimed to systematically analyze the components of AM and explore its effects on alcohol-induced chronic liver injury in mice. A component analysis of AM revealed 17 types of fatty acids, 17 types of amino acids, 8 types of minerals, and 3 types of nucleotides. Chronic alcohol-induced liver injury was established in mice via gradient alcohol feeding over a period of 6 months, with test groups orally receiving AM in the last 6 weeks. AM administration yielded potential hepatoprotective effects by alleviating weight gain and changes in organ indexes, decreasing the ratio of alanine aminotransferase\/aspartate aminotransferase, reducing lipid peroxidation, enhancing antioxidant activities, decreasing oxidation-related factor levels, and regulating inflammatory cytokine levels. Histological analyses suggest that AM treatment markedly prevented organ damage in alcohol-exposed mice. Furthermore, AM activated nuclear factor erythroid 2-like 2 (Nrf2) by downregulating the expression of Kelch-like ECH-associated protein 1, resulting in elevated downstream antioxidative enzyme levels. AM activated Nrf2 via modulation of the phosphatidylinositol-3-hydroxykinase\/protein kinase B signaling pathway. Altogether, AM prevented alcohol-induced liver injury, potentially by suppressing oxidative stress via the Nrf2 signaling pathway.<\/jats:p>","DOI":"10.1155\/2020\/4054520","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T23:31:47Z","timestamp":1578526307000},"page":"1-13","source":"Crossref","is-referenced-by-count":9,"title":["<i>Aronia melanocarpa<\/i>Prevents Alcohol-Induced Chronic Liver Injury via Regulation of Nrf2 Signaling in C57BL\/6 Mice"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-9888","authenticated-orcid":true,"given":"Zhuqian","family":"Wang","sequence":"first","affiliation":[{"name":"Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China"},{"name":"School of Life Sciences, Jilin University, Changchun 130012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yange","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Jilin University, Changchun 130012, China"},{"name":"School of Basic Medical Sciences, Nanchang University, Nanchang 330038, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1219-3570","authenticated-orcid":true,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-4174","authenticated-orcid":true,"given":"Di","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China"},{"name":"School of Life Sciences, Jilin University, Changchun 130012, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmu.2016.08.010"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-019-00231-x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217707729"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.10.023"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-009-0151-4"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4820414"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.4.R1049"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2012.11.015"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(96)00428-5"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002174"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2017.03.014"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.02.041"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X10378925"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i15.3892"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2016.00006"},{"issue":"6","key":"16","first-page":"32","year":"2011","journal-title":"Experimental & Clinical Gastroenterology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6410"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.05.005"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b04065"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666151112152143"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0715"},{"issue":"48","key":"22","first-page":"395","volume":"8","year":"2000","journal-title":"Polski Merkuriusz Lekarski"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1080\/09540105.2018.1541967"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/BF01338151"},{"issue":"2","key":"25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0021-9258(18)84848-7","volume":"65","year":"1925","journal-title":"Journal of Biological Chemistry"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1093\/treephys\/24.10.1129"},{"issue":"9","key":"27","first-page":"199","volume":"27","year":"1953","journal-title":"Dansk Tidsskrift for Farmaci"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s12088-016-0602-8"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2014.07.076"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00063.x"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12994"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80067-0"},{"issue":"9","key":"33","first-page":"61","volume":"38","year":"1976","journal-title":"Arkhiv Patologii"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.05.037"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1283-1"},{"issue":"17","key":"36","volume":"289","year":"2014","journal-title":"Journal of Biological Chemistry"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600294200"},{"issue":"5","key":"38","volume":"6","year":"2013","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5871431"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2358-6"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.03.035"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-015-0497-2"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1021\/jf904407x"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00138.2013"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2007.09.004"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1159\/000447279"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb07476.x"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2006.11.002"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01982.x"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.7.536"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-009-0432-0"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.20078"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7918261"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v8.i2.363"},{"issue":"11","key":"55","first-page":"1213","volume":"40","year":"2002","journal-title":"Indian Journal of Experimental Biology"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2016.04.015"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.052977"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.05.014"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4366-7"},{"issue":"2","key":"60","doi-asserted-by":"crossref","first-page":"405","DOI":"10.18388\/abp.2003_3694","volume":"50","year":"2003","journal-title":"Acta Biochimica Polonica"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030215"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-006-0239-5"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22702"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-010-0176-6"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.08.022"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4408"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-5668fje"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.05.023"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.07.057"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/4054520.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/4054520.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/4054520.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T23:40:51Z","timestamp":1613432451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2020\/4054520\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":69,"alternative-id":["4054520","4054520"],"URL":"https:\/\/doi.org\/10.1155\/2020\/4054520","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,8]]}}}