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Currently, there is no targeted therapy for myocardial fibrosis, which is highly associated with a large number of cardiovascular diseases and can lead to fatal heart failure. Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is an endogenous gasotransmitter similar to nitric oxide and carbon monoxide. H<jats:sub>2<\/jats:sub>S is involved in the suppression of oxidative stress, inflammation, and cellular death in the cardiovascular system. The level of H<jats:sub>2<\/jats:sub>S in the body can be boosted by stimulating its synthesis or supplying it exogenously with a simple H<jats:sub>2<\/jats:sub>S donor with a rapid- or slow-releasing mode, an organosulfur compound, or a hybrid with known drugs (e.g., aspirin). Hypertension, myocardial infarction, and inflammation are exaggerated when H<jats:sub>2<\/jats:sub>S is reduced. In addition, the exogenous delivery of H<jats:sub>2<\/jats:sub>S mitigates myocardial fibrosis caused by various pathological conditions, such as a myocardial infarct, hypertension, diabetes, or excessive <jats:italic>\u03b2<\/jats:italic>-adrenergic stimulation, via its involvement in a variety of signaling pathways. Numerous experimental findings suggest that H<jats:sub>2<\/jats:sub>S may work as a potential alternative for the management of myocardial fibrosis. In this review, the antifibrosis role of H<jats:sub>2<\/jats:sub>S is briefly addressed in order to gain insight into the development of novel strategies for the treatment of myocardial fibrosis.<\/jats:p>","DOI":"10.1155\/2020\/4105382","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T18:31:22Z","timestamp":1579804282000},"page":"1-14","source":"Crossref","is-referenced-by-count":40,"title":["Hydrogen Sulfide as a Potential Alternative for the Treatment of Myocardial Fibrosis"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-2237","authenticated-orcid":true,"given":"Se Chan","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Hwa","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department 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