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Although the psychiatric symptoms, especially for motivation and emotion, could be increased in schizophrenia, the underlying neural mechanisms remain poorly understood. We employed a longitudinal study to measure the alteration of striatum functional networks in schizophrenic subjects undergoing Mozart music listening using resting\u2010state functional magnetic resonance imaging (fMRI). Forty\u2010five schizophrenic inpatients were recruited and randomly assigned to two groups. Under the standard care with antipsychotic medication, one group received music intervention for 1 month and the other group is set as control. Both schizophrenic groups were compared to healthy subjects. Resting\u2010state fMRI was acquired from schizophrenic subjects at baseline and after one\u2010month music intervention and from healthy subjects at baseline. Striatum network was assessed through seed\u2010based static and dynamic functional connectivity (FC) analyses. After music intervention, increased static FC was observed between pallidum and ventral hippocampus in schizophrenic subjects. Increased dynamic FCs were also found between pallidus and subregions of default mode network (DMN), including cerebellum crus and posterior cingulate cortex. Moreover, static pallidus\u2010hippocampus FC increment was positively correlated with the improvement of negative symptoms in schizophrenic subjects. Together, these findings provided evidence that music intervention might have an effect on the FC of the striatum\u2010DMN circuit and might be related to the remission of symptoms of schizophrenia.<\/jats:p>","DOI":"10.1155\/2020\/4107065","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T23:30:46Z","timestamp":1600731046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Effects of Music Intervention on Pallidum\u2010DMN Circuit of 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