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(Amaranthaceae) is used in folk medicine as a natural analgesic, and in Brazil, the species of genus <jats:italic>Gomphrena<\/jats:italic> is used for rheumatism. However, scientific evidence which supports its popular use as an analgesic is scarce. This study assessed the antiarthritic and antihyperalgesic activities of the ethanolic extract obtained from <jats:italic>G<\/jats:italic>. <jats:italic>celosioides<\/jats:italic> aerial parts on Swiss or <jats:italic>C57BL\/6<\/jats:italic> mice. The antiarthritic and antihyperalgesic potential of <jats:italic>Gomphrena celosioides<\/jats:italic> was evaluated using paw edema, mechanical hyperalgesia, cold allodynia, carrageenan\u2010induced pleurisy, articular inflammation zymosan\u2010induced, Freund\u2019s complete adjuvant\u2010induced inflammation zymosan\u2010induced peritonitis, and carrageenan\u2010induced adhesion and rolling experiment models. All doses of <jats:italic>G<\/jats:italic>. <jats:italic>celosioides<\/jats:italic> (300, 700, and 1000\u2009mg\/kg) significantly reduced edema formation in all the intervals evaluated, whereas the mechanical hyperalgesia was reduced 3 hours after the carrageenan injection. The cold hyperalgesia was significantly decreased 3 (700\u2009mg\/kg) and 4 hours (700 and 1000\u2009mg\/kg) after the carrageenan injection. Ethanolic extract of <jats:italic>G<\/jats:italic>. <jats:italic>celosioides<\/jats:italic> at 1000\u2009mg\/kg reduced the total leukocyte number, without interfering in the protein extravasation in carrageenan\u2010induced pleurisy model. Ethanolic extract of <jats:italic>G<\/jats:italic>. <jats:italic>celosioides<\/jats:italic> (300\u2009mg\/kg) was also able to reduce significantly the leukocyte migration in zymosan\u2010induced articular edema, while a reduction of the adhesion and migration and leukocyte rolling was induced by the ethanolic extract of <jats:italic>G<\/jats:italic>. <jats:italic>celosioides<\/jats:italic> (300\u2009mg\/kg) in zymosan\u2010induced peritonitis. In Freund\u2019s complete adjuvant\u2010induced inflammation model, an edema formation and mechanical hyperalgesia reduction were induced by the ethanolic extract of <jats:italic>G<\/jats:italic>. <jats:italic>celosioides<\/jats:italic> on day 22, whereas the cold allodynia was reduced on day 6 of treatment with the extract. These results show that ethanolic extract of <jats:italic>G<\/jats:italic>. <jats:italic>celosioides<\/jats:italic> has antihyperalgesic and antiarthritic potential in different acute and persistent models, explaining, at least in part, the ethnopharmacological relevance of this plant as a natural analgesic agent.<\/jats:p>","DOI":"10.1155\/2020\/4170589","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T23:33:09Z","timestamp":1600212789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from <i>Gomphrena celosioides<\/i> Mart. (Amaranthaceae) Aerial Parts"],"prefix":"10.1155","volume":"2020","author":[{"given":"Luis Fernando Benitez","family":"Macorini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Alencar Santos","family":"Radai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8463-083X","authenticated-orcid":false,"given":"Rafael Souza","family":"Maris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo Euclides","family":"Silva-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maicon Matos","family":"Leitao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Faloni de","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayanna Isabel Araque","family":"Gelves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Jose","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle Cristina","family":"Arena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-9219","authenticated-orcid":false,"given":"C\u00e2ndida Aparecida Leite","family":"Kassuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"4650","article-title":"Downregulation of lncRNA ITSN1-2 correlates with decreased disease risk and activity of rheumatoid arthritis (RA), and reduces RA fibroblast-like synoviocytes proliferation and inflammation via inhibiting NOD2\/RIP2 signaling pathway","volume":"11","author":"Yue T.","year":"2019","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00215"},{"key":"e_1_2_10_3_2","first-page":"67","article-title":"Evaluation of the hepatoprotective activity of Gomphrena celosioides (Amaranthaceae) on wistar rats intoxicated with tetrachloride carbon","volume":"4","author":"Sangare M. 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