{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:36:24Z","timestamp":1789446984418,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":328,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313836"],"award-info":[{"award-number":["2016A030313836"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    There have been no robust data from clinical trials to guide the clinician in the choice of therapeutic agents for the child with intravenous immunoglobulin (IVIG) resistance. The treatment regimen for IVIG\u2010resistant patients varies between institutions, and the best option has not yet been established. Therefore, in this trial, a total of 955 patients with Kawasaki disease (KD) were selected and were initially treated with IVIG (2\u2009g\/kg), of whom 80 (8.38%) assessed as IVIG resistant were randomly divided into two groups: Group A received the second IVIG treatment (\n                    <jats:italic>n<\/jats:italic>\n                    = 40), and Group B received methylprednisolone pulse therapy (MPT,\n                    <jats:italic>n<\/jats:italic>\n                    = 40). The whole fever time, duration of fever after retreatment, hospital days, medical costs, readmission rate, and laboratory examination difference (\u25b3) were calculated. Coronary artery lesion (CAL) outcomes were followed up over two years. Patients in the MPT group had shorter fever after retreatment and lower medical costs; more rapid declines in C\u2010reactive protein (CRP), neutrophils (N%), and platelet (PLT) levels; and more rapid rise in sodium. However, they also probably had a higher incidence of treatment failure and CALs than the additional IVIG treatment group in the long\u2010term follow\u2010up. Caution is still required in the use of MPT to treat IVIG\u2010resistant KD.\n                  <\/jats:p>","DOI":"10.1155\/2020\/4175821","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T19:47:03Z","timestamp":1606247223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Methylprednisolone Pulse Therapy or Additional IVIG for Patients with IVIG\u2010Resistant Kawasaki Disease"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3449-7687","authenticated-orcid":false,"given":"Zhouping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-9317","authenticated-orcid":false,"given":"Feiyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-7498","authenticated-orcid":false,"given":"Yanfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7864-455X","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8118-1346","authenticated-orcid":false,"given":"Xiaofei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-8189","authenticated-orcid":false,"given":"Peiying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-8890","authenticated-orcid":false,"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0712-0112","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-754X","authenticated-orcid":false,"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"e_1_2_11_1_2","first-page":"178","article-title":"Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children","volume":"16","author":"Kawasaki T.","year":"1967","journal-title":"Arerug\u012b"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.082107"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70038-6"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061235"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199812000-00009"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31815922b5"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.126144"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80972-2"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145143.19711.78"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.05.025"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.6.e78"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70447-X"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000484"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2002.00855.x"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2182"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592865"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.03.050"},{"key":"e_1_2_11_18_2","first-page":"803","article-title":"Corticosteroid treatment of refractory Kawasaki disease","volume":"33","author":"Lang B. 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