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Peroxisome proliferator-activated receptor <jats:italic>\u03b1<\/jats:italic> (PPAR<jats:italic>\u03b1<\/jats:italic>) plays a crucial role in the control of lipid homeostasis. Here, we investigated the effects of CP775146, a new selective PPAR<jats:italic>\u03b1<\/jats:italic> agonist, on lipid metabolism in diet-induced obese mice and its possible mechanism. <jats:italic>Methods<\/jats:italic>. C57BL\/6 mice were fed a high-fat diet (HFD) for 12 weeks to induce obesity and then received CP775146 via intraperitoneal injection for 3 days. The content\/morphology of the liver, serum lipid, and liver function was measured. The expression of genes related to lipolysis and synthesis in liver was detected by quantitative real-time PCR (qRT-PCR). <jats:italic>Results<\/jats:italic>. The safe dose of CP775146 was &lt;0.3\u2009mg\/kg. CP775146 reduced the serum levels of liver enzymes, such as alanine aminotransferase (ALT) and glutamic-oxaloacetic transaminase (AST) and lipid metabolism-related biomarkers, including triglycerides (TGs) and low-density lipoprotein cholesterol (LDL-c), non-high-density lipoprotein cholesterol (non-HDL-c), and hepatic TG content, at a dosage of 0.1\u2009mg\/kg. HFD-induced pathological liver changes improved after CP775146 treatment. The expression of genes involved in liver fatty acid oxidation (acyl-coenzyme A dehydrogenase, long chain (<jats:italic>Acadl<\/jats:italic>), acyl-CoA oxidase 1 (<jats:italic>Acox<\/jats:italic>-<jats:italic>1<\/jats:italic>), carnitine palmitoyltransferase-1 (<jats:italic>CPT<\/jats:italic>-<jats:italic>1<\/jats:italic>), and enoyl-CoA, hydratase\/3-hydroxyacyl CoA dehydrogenase (<jats:italic>Ehhadh<\/jats:italic>)) was upregulated in CP775146-treated mice. Furthermore, CP775146 induced the expression of thermogenesis genes (cell death-inducing DFFA-like effector a (<jats:italic>Cidea<\/jats:italic>), uncoupling protein 1 (<jats:italic>Ucp1<\/jats:italic>)) and lipolysis genes (hormone-sensitive lipase (<jats:italic>Hsl<\/jats:italic>), adipose tissue triglyceride lipase (<jats:italic>Atgl<\/jats:italic>)) in epididymal white adipose tissue (eWAT), activating browning and thermogenesis. <jats:italic>Conclusion<\/jats:italic>. CP775146 efficiently alleviates obesity-induced liver damage, prevents lipid accumulation by activating the liver fatty acid <jats:italic>\u03b2<\/jats:italic>-oxidation pathway, and regulates the expression of genes that control brown fat-like pathway in eWAT.<\/jats:p>","DOI":"10.1155\/2020\/4179852","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T23:49:35Z","timestamp":1588722575000},"page":"1-9","source":"Crossref","is-referenced-by-count":12,"title":["The Effects of New Selective PPAR<i>\u03b1<\/i> Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism"],"prefix":"10.1155","volume":"2020","author":[{"given":"Shengjie","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihua","family":"Lin","sequence":"additional","affiliation":[{"name":"Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, The Affiliated Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, 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