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Sprague-Dawley (SPD) rats were pretreated for three days with 10 or 40\u2009mg\/kg\/d, ig of CA, and then induced with mesenteric ischemia for 1\u2009h and reperfusion for 2\u2009h. The results indicated that pretreatment with 10 or 40\u2009mg\/kg of CA attenuated morphological damage in both lung and liver tissues of mesenteric I\/R-injured rats. CA pretreatment significantly restored the levels of aspartate transaminase (AST) and alanine transaminase (ALT) in mesenteric I\/R-injured liver tissues, indicating the improvement of hepatic function. CA also significantly attenuated the inflammation via reducing myeloperoxidase (MOP) activity and downregulating the expression of inflammation-related proteins, including interleukin-6 (IL-6), interleukin-1\u03b2 (IL-1\u03b2), cyclooxygenase-2 (Cox-2), and tumor necrosis factor receptor type-2 (TNFR-2) in both lung and liver tissues of mesenteric I\/R-injured rats. Pretreatment with CA significantly downregulated nuclear factor kappa B- (NF-\u03baB-) related protein expressions (NF-\u03baB p65, NF-\u03baB p50, I kappa B alpha (IK-\u03b1), and inhibitor of nuclear factor kappa-B kinase subunit beta (IKK\u03b2)) in both lung and liver tissues of mesenteric I\/R-injured rats. CA also significantly downregulated the protein expression of p53 family members, including caspase-3, caspase-9, Bax, and p53, and restored Bcl-2 in both lung and liver tissues of mesenteric I\/R-injured rats. CA pretreatment significantly reduced TUNEL-apoptotic cells and significantly inhibited p53 and NF-\u03baB p65 nuclear translocation in both lung and liver tissues of mesenteric I\/R-injured rats. CA neither induced pulmonary and hepatic histological alterations nor affected the parameters of inflammation and apoptosis in sham rats. We conclude that CA alleviated mesenteric I\/R-induced pulmonary and hepatic injuries via attenuating apoptosis and inflammation through inhibition of NF-\u03baB and p53 pathways in rats, suggesting the potential role of CA in remote organ ischemic injury protection.<\/jats:p>","DOI":"10.1155\/2020\/4196548","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T16:36:15Z","timestamp":1607704575000},"page":"1-14","source":"Crossref","is-referenced-by-count":17,"title":["Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9068-5909","authenticated-orcid":true,"given":"Marwan","family":"Almoiliqy","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Pharmaceutical College, Dalian Medical University, Dalian 116044, China"},{"name":"Key Lab of Aromatic Plant Resources Exploitation and 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