{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:57:37Z","timestamp":1778857057038,"version":"3.51.4"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":274,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970186"],"award-info":[{"award-number":["81970186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR\u2010T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed\/refractory (r\/r) hematological malignancies. Of note, CD19, CD20, CD30, CD33, CD123, and CD269 as ideal targets have shown extraordinary potential for CAR\u2010T cell therapy and other targets such as CD23 and SLAMF7 have brought promising future for clinical trials. However, CAR\u2010T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on\u2010target\/off\u2010tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood\u2010brain barrier, and even normal tissue damage. In this review, we aim to summarize the composition of CAR\u2010T cell and its application in the treatment of acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), non\u2010Hodgkin\u2019s lymphoma (NHL), Hodgkin\u2019s lymphoma (HL), multiple myeloma (MM), and acute myeloid leukemia (AML). Moreover, we will review the disadvantages of CAR\u2010T cell therapy and propose several comprehensive recommendations which might guide its development.<\/jats:p>","DOI":"10.1155\/2020\/4241864","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T01:20:12Z","timestamp":1601601612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Application of Chimeric Antigen Receptor T Cells in the Treatment of Hematological Malignancies"],"prefix":"10.1155","volume":"2020","author":[{"given":"Weiqi","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-6971","authenticated-orcid":false,"given":"Zhuojun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanshi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3967-8460","authenticated-orcid":false,"given":"Kai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2774-6270","authenticated-orcid":false,"given":"Jian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"2176","article-title":"Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene","volume":"58","author":"Smith M. T.","year":"1998","journal-title":"Cancer Research"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2013.0422"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-003-0773-3"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12020194"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871520615666150824153523"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2015.05.009"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000481"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00649.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4933-9-23"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13193"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.031"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.05.032"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.10.007"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2012.6"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1706169"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0813-7"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-017-0102-y"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4597"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1049"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3838"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2012.1.143.3798224"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-1097"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2015.1046430"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1610544113"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.09.002"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-019-2118-z"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000568"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215134"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709866"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(16)35779-3"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2020-001290"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.110"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103849"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac5415"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.05.018"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002936"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.03.014"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2025"},{"key":"e_1_2_9_39_2","article-title":"Outcomes in refractory aggressive diffuse large B cell lymphoma (DLBCL): results from the international SCHOLAR-1 study","volume":"16","author":"Crump M.","year":"2017","journal-title":"Clinical Lymphoma Myeloma & Leukemia"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708566"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30928-2"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-387969"},{"key":"e_1_2_9_44_2","first-page":"117","article-title":"An interim analysis of the ZUMA-1 study of KTE-C19 in refractory, aggressive non-Hodgkin lymphoma","volume":"15","author":"Neelapu S. S.","year":"2017","journal-title":"Clinical Advances in Hematology & Oncology : H&O"},{"key":"e_1_2_9_45_2","article-title":"CAR T-cell therapy for a relapsed\/refractory acute B-cell lymphoblastic lymphoma patient in the context of Li-Fraumeni syndrome","volume":"8","author":"Chen L.","year":"2019","journal-title":"Journal for Immunotherapy of Cancer"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-020-03198-7"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94306"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1365"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04355.x"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13889"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4431"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0672-7"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26792"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-778423"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.4161\/onci.28835"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.08.001"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2019-1428"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2018.03.006"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2013.01.003"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707447"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2020.03.483"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03685-z"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.148"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-018-0582-9"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0698"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-03-900985"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-881722"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.12.452"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2018.03.001"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0379-6"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.011"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.011"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.012"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006597"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-017-0070-9"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2013.32"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0697"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.09.010"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.18609\/cgti.2018.028"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84813"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00254"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-628354"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/4241864.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/4241864.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/4241864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T08:09:55Z","timestamp":1735632595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/4241864"}},"subtitle":[],"editor":[{"given":"YangQiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/4241864"],"URL":"https:\/\/doi.org\/10.1155\/2020\/4241864","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4241864"}}