{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:26:10Z","timestamp":1761845170972,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":79,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Changsha Science and Technology Bureau","award":["kq1701095","2017SK50105"],"award-info":[{"award-number":["kq1701095","2017SK50105"]}]},{"name":"Department of Science and Technology of Hunan Province of China","award":["kq1701095","2017SK50105"],"award-info":[{"award-number":["kq1701095","2017SK50105"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Because of the poor prognosis for high\u2010grade glioma (HGG) patients, it is important to increase the dose of the tumor to improve the efficacy while minimizing the dose of organs at risk (OARs). Thus, we evaluated the potential dosimetric gains of helical tomotherapy (HT) versus intensity\u2010modulated radiotherapy (IMRT) or volume\u2010modulated arc therapy (VMAT) for high\u2010grade glioma (HGG). <jats:italic>Methods<\/jats:italic>. A total of 42 HGG patients were retrospectively selected who had undergone helical tomotherapy; then, IMRT and VMAT plans were generated and optimized for comparison after contouring crucial neuronal structures for neurogenesis and neurocognitive function. IMRT and VMAT were optimized with the Eclipse treatment planning system (TPS) (Version 11.0.31) and HT using TomoTherapy Hi\u2010Art Software (Version 2.0.7) (Accuray, Madison, WI, USA). All three techniques were optimized for simultaneously delivering 60\u2009Gy to planning target volume (PTV) 1 and 50\u201054\u2009Gy to PTV2. We also analyzed the homogeneity index (HI) and conformity index (CI) of PTVs and organ at risk (OAR) sparing. <jats:italic>Results<\/jats:italic>. There was no significant difference in the PTV coverage among IMRT, VMAT, or HT. As for the HI, HT plans (PTV1 HI: 0.09 \u00b1 0.03, PTV2 HI: 0.17 \u00b1 0.05) had the best homogeneity when compared to IMRT plans (PTV1 HI: 0.10 \u00b1 0.04, PTV2 HI: 0.18 \u00b1 0.04) and VMAT plans (PTV1 HI: 0.11 \u00b1 0.03, PTV2 HI: 0.20 \u00b1 0.03). The CI value of HT (PTV1 CI: 0.98 \u00b1 0.03, PTV2: 0.98 \u00b1 0.05) was closest to the optimal value. Except for the IMRT and VMAT groups, there were statistically significant differences between the other two groups of the CI values in both PTV1 and PTV2. The other comparison values were statistically significant except for the optic nerve, and VMAT had the best sparing of the optic chiasm. The mean and max doses of OARs declined significantly in HT. <jats:italic>Conclusions<\/jats:italic>. For high\u2010grade glioma patients, HT had superior outcomes in terms of PTV coverage and OAR sparing as compared with IMRT\/VMAT.<\/jats:p>","DOI":"10.1155\/2020\/4258989","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T23:32:40Z","timestamp":1584747160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of Dosimetric Gains Provided by Intensity\u2010Modulated Radiotherapy, Volume\u2010Modulated Arc Therapy, and Helical Tomotherapy for High\u2010Grade 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