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The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood. In this study, we aimed to investigate the effect of PM2.5 on lung injury in rats with hallmark features of COPD. Cardinal features of human COPD were induced in a rat model by repeated cigarette smoke inhalation and bacterial infection for 8 weeks. Then, from week 9 to week 16, some of these rats with COPD were subjected to real-time concentrated atmospheric PM2.5. Lung function, pathology, inflammatory cytokines, oxidative stress, and mucus and collagen production were measured. As expected, the COPD rats had developed emphysema, inflammation, and deterioration in lung function. PM2.5 exposure resulted in greater lung function decline and histopathological changes, as reflected by increased Mucin (MUC) 5ac, MUC5b, Collagen I, Collagen III, and the profibrotic cytokine <jats:italic>\u03b1<\/jats:italic>-smooth muscle-actin (SMA), transforming growth factor- (TGF-) <jats:italic>\u03b2<\/jats:italic>1 in lung tissues. PM2.5 also aggravated inflammation, increasing neutrophils and eosinophils in bronchoalveolar lavage fluid (BALF) and cytokines including Interleukin- (IL-) 1<jats:italic>\u03b2<\/jats:italic>, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-4. The likely mechanism is through oxidative stress as antioxidants levels were decreased, whereas oxidants were increased, indicating a detrimental shift in the oxidant-antioxidant balance. Altogether, these results suggest that PM2.5 exposure could promote the development of COPD by impairing lung function and exacerbating pulmonary injury, and the potential mechanisms are related to inflammatory response and oxidative stress.<\/jats:p>","DOI":"10.1155\/2020\/4260204","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:30:56Z","timestamp":1588966256000},"page":"1-12","source":"Crossref","is-referenced-by-count":46,"title":["Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD"],"prefix":"10.1155","volume":"2020","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou 450046, China"},{"name":"Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. 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