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This activity was tested <jats:italic>in vitro<\/jats:italic> by using the microdilution method and the checkerboard assay. The efficacy of these three antibacterial agents was then tested <jats:italic>in vivo<\/jats:italic> by using an experimental model of methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic> osteomyelitis in rabbits. This efficacy was assessed after four days of treatment by counting the number of bacteria in the bone marrow. The obtained results <jats:italic>in vitro<\/jats:italic> showed that the combination of the AMC with gentamicin did not induce a synergistic effect, whereas the combination of the two antibiotics with 1,8\u2010cineole did. This effect is stronger when AMC is combined with 1,8\u2010cineole as a total synergistic effect was obtained on the three strains used (FIC\u2009\u2264\u20090.5). <jats:italic>In vivo<\/jats:italic>, a significant reduction was noted in the number of colonies in the bone marrow when rabbits were treated with AMC associated with either 1,8\u2010cineole or gentamicin compared to rabbits treated with AMC, gentamicin, or 1,8\u2010cineole alone. These results demonstrated that 1,8\u2010cineole showed a synergistic effect in combination with both AMC and gentamicin, which offer possibilities for reducing antibiotic usage. Also, the AMC associated with 1,8\u2010cineole could be used to treat MRSA osteomyelitis.<\/jats:p>","DOI":"10.1155\/2020\/4271017","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T23:46:35Z","timestamp":1588203995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The Antistaphylococcal Activity of Amoxicillin\/Clavulanic Acid, Gentamicin, and 1,8\u2010Cineole Alone or in Combination and Their Efficacy through a Rabbit Model of Methicillin\u2010Resistant <i>Staphylococcus aureus<\/i> Osteomyelitis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Soukayna","family":"Hriouech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Akhmouch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aouatef","family":"Mzabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanane","family":"Chefchaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Tanghort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouchra","family":"Oumokhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najat","family":"Chami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7936-0871","authenticated-orcid":false,"given":"Adnane","family":"Remmal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1984-82502013000100003"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-019-04505-2"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1213956"},{"key":"e_1_2_9_4_2","volume-title":"Le Profil Epidemiologique des Infections Osteo-Articulaires Chez l\u2019enfant (A Propos de 264 Cas)","author":"El hamdi F. 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