{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:34:34Z","timestamp":1768350874885,"version":"3.49.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"vor","delay-in-days":164,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Traditional Chinese Medicine Science and Technology Programme Project of Health and Wellness Committee of Jiangxi Province","award":["2018A393"],"award-info":[{"award-number":["2018A393"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Clinical investigators have found that the use of needling in the treatment of ankylosing spondylitis (AS) has a good clinical application prospect in recent years. However, these studies were insufficient to provide evidence for the efficacy and safety of simple\u2010needling for AS. So, we performed a systematic review and meta\u2010analysis to evaluate the efficacy and safety of simple\u2010needling for treating AS. <jats:italic>Methods<\/jats:italic>. We searched the PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Wangfang database (Wanfang), Chinese Science and Technology Periodical Database (VIP), and any other gray literature sources for randomized controlled trials (RCTs) that used simple\u2010needling to treat AS before June 2019 with the language restriction of Chinese and English. Researchers evaluated the retrieved literature studies and extracted valid data according to relevant requirements and used RevMan5.3 software for meta\u2010analysis. <jats:italic>Results<\/jats:italic>. A total of 10 studies were included, all of which were Chinese literature studies, involving 729 patients. Compared with the control groups, simple\u2010needling groups had a better effect on the clinical effective rate (RR\u2009=\u20091.20, 95% CI (1.11, 1.29), <jats:italic>P<\/jats:italic> &lt; 0.00001), TCM syndrome score (MD\u2009=\u2009\u22125.26, 95% CI (\u22125.99, \u22124.53), <jats:italic>P<\/jats:italic> &lt; 0.00001), symptom score (MD\u2009=\u2009\u22128.08, 95% CI (\u221210.18, \u22125.97), <jats:italic>P<\/jats:italic> &lt; 0.00001), and Schober test outcome (MD\u2009=\u20090.39, 95% CI (0.15, 0.64), <jats:italic>P<\/jats:italic> = 0.002). Sensibility analysis was based on the leave\u2010one\u2010out cross\u2010validation procedure, and the results showed no significant changes. Most studies did not describe adverse reactions. The funnel plot suggested publication bias on clinical effectiveness. <jats:italic>Conclusions<\/jats:italic>. This systematic review and meta\u2010analysis demonstrated that simple\u2010needling was effective as an intervention for AS. However, due to the low quality of the methodology of included studies, the designs of clinical trials were not rigorously standardized. Therefore, it is necessary to carry out multiquality RCTs for verification.<\/jats:p>","DOI":"10.1155\/2020\/4276380","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T23:31:10Z","timestamp":1592091070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Efficacy and Safety of Simple\u2010Needling Therapy for Treating Ankylosing Spondylitis: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-8791","authenticated-orcid":false,"given":"Yichen","family":"Xuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2601-4665","authenticated-orcid":false,"given":"Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duanyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuwu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lele","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,13]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(07)60635-7"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0000000000000475"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket387"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3660-3"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1315-z"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.04.002"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.116178"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20408"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0418-z"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.863969"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2927-5"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2912-z"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/maj.0b013e3182514059"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.41042"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu438"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160594"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2016-000259"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-161"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000010790"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000021315"},{"key":"e_1_2_10_21_2","first-page":"41","article-title":"Clinical study of du-moxibustion combined with needling huatuo Jiaji acupoint in the treatment of AS of kidney-yang deficiency","volume":"35","author":"Ren Y. 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