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Interleukin\u201033 (IL\u201033) is a proinflammatory cytokine which is highly expressed in the synovium of RA patients and the joints of mice with collagen\u2010induced arthritis (CIA) and exacerbates CIA in mice. However, the role of the IL\u201033\u2010neutralizing antibody in the murine model of CIA remains unclear. In the present study, CIA mice were given intraperitoneally with polyclonal rabbit anti\u2010murine IL\u201033 antibody (anti\u2010IL\u201033) or normal rabbit IgG control after the first signs of arthritis. Administration of anti\u2010IL\u201033 after the onset of disease significantly reduced the severity of CIA and joint damage compared with controls treated with normal rabbit IgG. Anti\u2010IL\u201033 treatment also significantly decreased the serum levels of interferon\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    (IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    ),IL\u20106, IL\u201012, IL\u201033, and tumor necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ). Moreover, anti\u2010IL\u201033 treatment significantly downregulated the production of IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    , IL\u20106, IL\u201012, IL\u201033, and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    in ex vivo\u2010stimulated spleen cells. Together, our results indicate that the IL\u201033\u2010neutralizing antibody may provide a therapeutic strategy for RA by inhibiting the release of proinflammatory cytokines.\n                  <\/jats:p>","DOI":"10.1155\/2020\/4297354","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T19:11:05Z","timestamp":1604603465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Blocking Interleukin\u201033 Alleviates the Joint Inflammation and Inhibits the Development of Collagen\u2010Induced Arthritis in 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