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Our previous findings suggested that the 95% EtOH extract of <jats:italic>Wikstroemia indica<\/jats:italic> (L.) C. A. Mey. has antiallergic and anti\u2010inflammatory effects in DNCB\u2010treated CHS SKH\u20101 hairless mice. The aim of this study was to evaluate the protective effects of compounds isolated from the EtOAc fraction of <jats:italic>W. indica<\/jats:italic> in RBL\u20102H3 cells and 2,4\u2010dinitrochlorobenzene\u2010 (DNCB\u2010) induced CHS mice. Of eight compounds in <jats:italic>W. indica<\/jats:italic>, that is, umbelliferone, daphnoretin, wikstrocoumarin, (+)\u2010syringaresinol, tricin, (+)\u2010lariciresinol, <jats:italic>erythro<\/jats:italic>\u2010guaiacylglycerol\u2010<jats:italic>\u03b2<\/jats:italic>\u2010coniferyl ether, and quercitrin, quercitrin exhibited the most antiallergic activity against antigen\u2010induced <jats:italic>\u03b2<\/jats:italic>\u2010hexosaminidase release and IL\u20104 mRNA expression, which are markers of degranulation in RBL\u20102H3 cells. After a 7\u2010sensitizing period, 14 days of DNCB treatment with or without topical pimecrolimus (1%) or quercitrin (0.5%) treatment, quercitrin was found to suppress DNCB\u2010induced increases in serum IL\u20104 and IgE concentrations and transepidermal water loss. These results indicate that quercitrin has therapeutic potential for treatment of allergies and allergy\u2010related contact dermatitis.<\/jats:p>","DOI":"10.1155\/2020\/4307161","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T23:43:56Z","timestamp":1594338236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Quercitrin, the Main Compound in <i>Wikstroemia indica<\/i>, Mitigates Skin Lesions in a Mouse Model of 2,4\u2010Dinitrochlorobenzene\u2010Induced Contact 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