{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:27:07Z","timestamp":1776140827810,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":294,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702058"],"award-info":[{"award-number":["81702058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701995"],"award-info":[{"award-number":["81701995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Human adenoviruses (HAdVs) are commonly causing respiratory disease. We molecularly genotyped HAdV circulating in Chinese hospitalized children with respiratory infections and summarized the clinical profiles and common inflammatory biomarkers, so as to better determine their associations with disease severity. <jats:italic>Method<\/jats:italic>. Children with respiratory single HAdV infection cases that occurred from December 2017 to March 2019 were enrolled for a cross\u2010sectional study. Clinical\/laboratory features based on the genotypes of respiratory HAdV infection were reviewed for comparative analysis. <jats:italic>Results<\/jats:italic>. A total of 84 patients were enrolled, and HAdV types were identified from 82 patients. Species B (HAdV\u20107, 44%; HAdV\u20103, 43%, and HAdV\u201014, 5%) was the most common, followed by C (HAdV\u20102, 4% and HAdV\u20101, 1%) and E (HAdV\u20104, 1%). Severe HAdV infection and HAdV\u20107 infection groups were associated with significantly longer duration of fever and hospitalized days, higher morbidity of tachypnea\/dyspnea, more pleural effusion, more respiratory rales, more frequently required mechanical ventilation, and significantly higher fatality rate. The elevated procalcitonin (PCT) and C\u2010reactive protein (CRP) levels were significantly associated with severe HAdV infection. <jats:italic>Conclusions<\/jats:italic>. HAdV\u20107 and HAdV\u20103 were the most common types among children with respiratory adenovirus infection; vaccines against these two genotypes are in urgent need. PCT and CRP are significantly associated with the severity of HAdV infection.<\/jats:p>","DOI":"10.1155\/2020\/4357910","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T18:05:08Z","timestamp":1603303508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Molecular Epidemiology and Clinical Features Analysis of Respiratory Adenovirus Infections Reveals Correlations between Genotype, Inflammatory Biomarkers, and Disease Severity"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6188-5111","authenticated-orcid":false,"given":"Hui","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4875-4904","authenticated-orcid":false,"given":"Hongli","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3668-9770","authenticated-orcid":false,"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-8550","authenticated-orcid":false,"given":"Zhaohu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-0983","authenticated-orcid":false,"given":"Yike","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-5541","authenticated-orcid":false,"given":"Yongcai","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3118-934X","authenticated-orcid":false,"given":"Jun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1819-9567","authenticated-orcid":false,"given":"Ling","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-5557","authenticated-orcid":false,"given":"Zhiwu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584923"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000221"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1032"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00116-13"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1186"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/522188"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-014-2308-8"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep37216"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2017.78"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/519938"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-23"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1811.120629"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0911.030088"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02446-09"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-013-3308-7"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155412"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123234"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25333"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2016.11.004"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053614"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.08.051"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80624-7"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0562-4"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25032"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003577"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-314307"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00655-10"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300178"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-018-1188-x"},{"key":"e_1_2_11_30_2","first-page":"345","article-title":"Serum C-reactive protein in children with adenovirus infection","volume":"132","author":"Appenzeller C.","year":"2002","journal-title":"Swiss Medical Weekly"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200205000-00004"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00114-6"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/4357910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/4357910.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/4357910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T07:46:00Z","timestamp":1735631160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/4357910"}},"subtitle":[],"editor":[{"given":"Salvatore","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/4357910"],"URL":"https:\/\/doi.org\/10.1155\/2020\/4357910","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4357910"}}