{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:37:48Z","timestamp":1747190268378,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2020,3,20]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. This case series demonstrate diagnostic features, treatment options, and challenges for Brittle Cornea Syndrome.<jats:italic>Observations<\/jats:italic>. Three cases presented with bluish sclera and extremely thin cornea. Genetic workup was performed and confirmed the diagnosis of Brittle Cornea Syndrome, a rare autosomal recessive disorder characterized by corneal thinning and blue sclera. Case 1 was a 4-year-old boy who developed cataract and glaucoma after undergoing right tectonic penetrating keratoplasty (PK) secondary to a spontaneous corneal rupture. Glaucoma was controlled medically. Later, the kid underwent right transcorneal lensectomy and vitrectomy with synechiolysis. After 6 weeks, he sustained graft dehiscence that was repaired using onlay patch graft. Case 2 was a 7-year-old boy who underwent PK in the right eye, then a pericardial patch graft in the left eye following spontaneous corneal rupture. Glaucoma in both eyes was controlled medically. Case 3 was the 2-year-old sister of the 2<jats:sup>nd<\/jats:sup>case. She had a pachymetry of 238\u2009<jats:italic>\u03bc<\/jats:italic>m OD and 254\u2009<jats:italic>\u03bc<\/jats:italic>m OS. In the 3 cases, parents were instructed to take protective measures for both eyes and to continue with follow-up visits. Also, they were instructed to have regular screenings for late-onset hearing loss, dental abnormalities, and bone deformities.<jats:italic>Conclusions<\/jats:italic>. Long-term follow-up of children diagnosed with Brittle Cornea Syndrome is paramount to minimize the morbidity of corneal rupture and late-onset extraocular conditions.<\/jats:p>","DOI":"10.1155\/2020\/4381273","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T23:32:43Z","timestamp":1584747163000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Case Series of Brittle Cornea Syndrome"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3107-2106","authenticated-orcid":true,"given":"Taher","family":"Eleiwa","sequence":"first","affiliation":[{"name":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA"},{"name":"Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Raheem","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimesh A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audina M.","family":"Berrocal","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana","family":"Grajewski","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4508-0492","authenticated-orcid":true,"given":"Mohamed","family":"Abou Shousha","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2017.1313993"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.04.014"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-018-0903-2"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-68"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200303000-00017"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-014-3053-9"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000393"},{"year":"2012","key":"8"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.07.006"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000668"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000577"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000002002"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-223824"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(91)32271-1"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2014.959201"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2019.1659975"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.06.009"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000237"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.156927"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1177\/1120672118795060"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.101253"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.99976"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2017.10.007"},{"issue":"6","key":"24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3928\/1542-8877-19970601-09","volume":"28","year":"1997","journal-title":"Ophthalmic Surgery and Lasers"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2020\/4381273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2020\/4381273.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2020\/4381273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T11:29:16Z","timestamp":1666178956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criopm\/2020\/4381273\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,20]]},"references-count":24,"alternative-id":["4381273","4381273"],"URL":"https:\/\/doi.org\/10.1155\/2020\/4381273","relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"type":"print","value":"2090-6722"},{"type":"electronic","value":"2090-6730"}],"subject":[],"published":{"date-parts":[[2020,3,20]]}}}