{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:32:47Z","timestamp":1780360367473,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":159,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971643"],"award-info":[{"award-number":["81971643"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801736"],"award-info":[{"award-number":["81801736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background and Purpose<\/jats:italic>. Angioimmunoblastic T\u2010cell lymphoma (AITL) is a rare subtype of peripheral T\u2010cell lymphoma with rapid disease progression and poor prognosis. The aim of this study was to determine the incremental prognostic value of baseline <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography (<jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT) in addition to clinical prognostic factors. <jats:italic>Methods<\/jats:italic>. From January 2010 to October 2019, a total of 23 patients who pathologically confirmed to have AITL were retrospectively analyzed. All patients underwent whole\u2010body <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT scan before chemotherapy. The <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT features, clinical data, laboratory indicators, Ki67 labeling index, and survival status were collected and analyzed. <jats:italic>Results<\/jats:italic>. The median follow\u2010up was 22 months. The expected 1\u2010, 2\u2010, and 3\u2010year survival rate was 72.2%, 49.6%, and 42.5%, respectively. The median overall survival (OS) was 23 months (95% confidence interval (CI): 8.459~37.541). AITL is prone to extranodal infiltration, in addition to nodal infiltration (6 patients had nodal infiltration alone, and 17 patients had both nodal and extranodal infiltration). The SUV<jats:sub>max<\/jats:sub> of nodal lesions were higher than that for the extranodal lesions (10.43 \u00b1 4.45, 6.64 \u00b1 3.51, <jats:italic>F<\/jats:italic> = 2.78, <jats:italic>t<\/jats:italic> = 4.39, <jats:italic>P<\/jats:italic> &lt; 0.01). On multivariate survival analysis, the Eastern Cooperative Oncology Group (ECOG) and SUV<jats:sub>max<\/jats:sub> of extranodal lesions were independent predictors of OS. <jats:italic>Conclusion<\/jats:italic>. Baseline <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT results and SUV<jats:sub>max<\/jats:sub> of extranodal lesions showed an incremental prognostic value in addition to clinical prognostic factors.<\/jats:p>","DOI":"10.1155\/2020\/4502489","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T23:31:33Z","timestamp":1591659093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Incremental Prognostic Value of Baseline <sup>18<\/sup>F\u2010FDG PET\/CT Imaging in Angioimmunoblastic T\u2010Cell 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