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Its mechanism of action in preventing hepatic steatosis and obesity\u2010related disorders has yet to be clarified. The purpose of this research was to examine kaempferol\u2019s antiobesity effects in high\u2010fat diet\u2010 (HFD\u2010) fed mice and to investigate its impact on their gut microbiota. Using a completely randomized design, 30 mice were equally assigned to a control group, receiving a low\u2010fat diet, an HFD group, receiving a high\u2010fat diet, and an HFD+kaempferol group, receiving a high\u2010fat diet and kaempferol doses of 200\u2009mg\/kg in the diet. After eight weeks, the HFD mice displayed substantial body and liver weight gain and high blood glucose and serum cholesterol levels. However, treatment with kaempferol moderated body and liver weight gain and elevation of blood glucose and serum cholesterol and triglyceride levels. Examination of 16S ribosomal RNA showed that HFD mice exhibited decreased microbial diversity, but kaempferol treatment maintained it to nearly the same levels as those in the control group. In conclusion, kaempferol can protect against obesity and insulin resistance in mice on a high\u2010fat diet, partly through regulating their gut microbiota and moderating the decrease in insulin resistance.<\/jats:p>","DOI":"10.1155\/2020\/4532482","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T19:31:09Z","timestamp":1586287869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Preventive Effects of Kaempferol on High\u2010Fat Diet\u2010Induced Obesity Complications in C57BL\/6 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