{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:51:13Z","timestamp":1770511873503,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":320,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CB-2012\/176983"],"award-info":[{"award-number":["CB-2012\/176983"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>According to their oncogenic properties, Human Papillomaviruses (HPVs) are classified into two types: Low\u2010Risk (LR\u2010HPVs) and High\u2010Risk Human Papillomaviruses (HR\u2010HPVs). The immune system naturally controls the majority of HPV infections; however, when the HR\u2010HPV infection is persistent, the risk of developing cervical cancer increases. Previous studies indicate that multiple\u2010infection or coinfection with HR\u2010HPV occurs frequently and can potentiate the development of cervical lesions. This study aimed to establish the HPV coinfection rate in squamous intraepithelial lesions from Mexican patients. For HPV detection, we performed PCR on 55 cervical lesions diagnosed by colposcopy. We detected the presence of HPV infection in 87.27% (48\/55) of the lesions; interestingly, HPV coinfection was observed in 70.83% (34\/48) of these samples. We also evaluated HPV infection in adjacent areas without morphological changes from 25 samples. The results showed that 80% (20\/25) of these were HPV\u2010positive and, curiously, all presented HPV\u201016 infection. In conclusion, our results revealed a high prevalence of HPV coinfection in cervical lesions in Mexican patients, and these results contribute to future research focused on the role that HPV coinfection plays in the development of cervical cancer.<\/jats:p>","DOI":"10.1155\/2020\/4542320","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T08:16:56Z","timestamp":1605601016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Human Papillomavirus Coinfection in the Cervical Intraepithelial Lesions and Cancer of Mexican Patients"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3054-786X","authenticated-orcid":false,"given":"Juan 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