{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:01:50Z","timestamp":1774526510891,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MMV Challenge Grant","award":["MMV-12\/0087"],"award-info":[{"award-number":["MMV-12\/0087"]}]},{"name":"MMV Challenge Grant","award":["SL2012-2"],"award-info":[{"award-number":["SL2012-2"]}]},{"name":"Seeding Labs\u2019 2012 Instrumental Access Grant","award":["MMV-12\/0087"],"award-info":[{"award-number":["MMV-12\/0087"]}]},{"name":"Seeding Labs\u2019 2012 Instrumental Access Grant","award":["SL2012-2"],"award-info":[{"award-number":["SL2012-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2020,6,29]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>.<jats:italic>Terminalia mantaly<\/jats:italic>is used in Cameroon traditional medicine to treat malaria and related symptoms. However, its antiplasmodial efficacy is still to be established.<jats:italic>Objectives<\/jats:italic>. The present study is aimed at evaluating the<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>antiplasmodial activity and the oral acute toxicity of the<jats:italic>Terminalia mantaly<\/jats:italic>extracts.<jats:italic>Materials and Methods<\/jats:italic>. Extracts were prepared from leaves and stem bark of<jats:italic>T. mantaly<\/jats:italic>, by maceration in distilled water, methanol, ethanol, dichloromethane (DCM), and hexane. All extracts were initially screened<jats:italic>in vitro<\/jats:italic>against the chloroquine-resistant strain W2 of<jats:italic>P. falciparum<\/jats:italic>to confirm its<jats:italic>in vitro<\/jats:italic>activity, and the most potent one was assessed in malaria mouse model at three concentrations (100, 200, and 400\u2009mg\/kg\/bw). Biochemical, hematological, and histological parameters were also determined.<jats:italic>Results<\/jats:italic>. Overall, 7 extracts showed<jats:italic>in vitro<\/jats:italic>antiplasmodial activity with IC<jats:sub>50<\/jats:sub>ranging from 0.809\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL to 5.886\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. The aqueous extract from the stem bark of<jats:italic>T. mantaly<\/jats:italic>(<jats:italic>Tm<\/jats:italic>sb<jats:sup>w<\/jats:sup>) was the most potent (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mtext>I<\/mml:mtext><mml:msub><mml:mrow><mml:mtext>C<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>50<\/mml:mn><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>0.809<\/mml:mn><mml:mtext>\u2009<\/mml:mtext><mml:mi>\u03bc<\/mml:mi><mml:mtext>g<\/mml:mtext><mml:mo>\/<\/mml:mo><mml:mtext>mL<\/mml:mtext><\/mml:math>) and was further assessed for acute toxicity and efficacy in<jats:italic>Plasmodium berghei<\/jats:italic>-infected mice.<jats:italic>Tm<\/jats:italic>sb<jats:sup>w<\/jats:sup>was safe in mice with a median lethal dose (LD<jats:sub>50<\/jats:sub>) higher than 2000\u2009mg\/kg of body weight. It also exerted a good antimalarial efficacy<jats:italic>in vivo<\/jats:italic>with ED<jats:sub>50<\/jats:sub>of 69.50\u2009mg\/kg and had no significant effect on biochemical, hematological, and histological parameters.<jats:italic>Conclusion<\/jats:italic>. The results suggest that the stem bark extract of<jats:italic>T. mantaly<\/jats:italic>possesses antimalarial activity.<\/jats:p>","DOI":"10.1155\/2020\/4580526","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T23:31:30Z","timestamp":1593473490000},"page":"1-9","source":"Crossref","is-referenced-by-count":13,"title":["<i>In Vivo<\/i>Antiplasmodial Activity of<i>Terminalia mantaly<\/i>Stem Bark Aqueous Extract in Mice Infected by<i>Plasmodium berghei<\/i>"],"prefix":"10.1155","volume":"2020","author":[{"given":"Mariscal Brice","family":"Tchatat Tali","sequence":"first","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaound\u00e9 1, PO Box 812, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric Derick","family":"Jiatsa Mbouna","sequence":"additional","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaound\u00e9 1, PO Box 812, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauve Rachel","family":"Yamthe Tchokouaha","sequence":"additional","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaound\u00e9 1, PO Box 812, Yaound\u00e9, Cameroon"},{"name":"Institute for Medical Research and Medicinal Plants Studies (IMPM), Yaound\u00e9, PO Box 6163, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-3527","authenticated-orcid":true,"given":"Patrick Valere","family":"Tsouh Fokou","sequence":"additional","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaound\u00e9 1, PO Box 812, Yaound\u00e9, Cameroon"},{"name":"Department of Biochemistry, Faculty of Science, University of Bamenda, PO Box 39, Bambili, Bamenda, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaures Marius","family":"Tsakem Nangap","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaound\u00e9 1, PO Box 812, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigue","family":"Keumoe","sequence":"additional","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaound\u00e9 1, PO Box 812, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvine","family":"Ngoutane Mfopa","sequence":"additional","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaound\u00e9 1, PO Box 812, Yaound\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issakou","family":"Bakarnga-via","sequence":"additional","affiliation":[{"name":"Antimicrobial & Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaound\u00e9 1, PO Box 812, Yaound\u00e9, Cameroon"},{"name":"Department of Biomedical and Pharmaceutical Sciences, Faculty of Human Health Sciences, University of Ndjamena, PO Box 1117, Ndjamena, Chad"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raceline","family":"Gounoue Kamkumo","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaound\u00e9 1, PO Box 812, Yaound\u00e9, 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