{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:56:04Z","timestamp":1789145764020,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":267,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7192166"],"award-info":[{"award-number":["7192166"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972944"],"award-info":[{"award-number":["81972944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    . Both thymic stromal lymphopoietin (TSLP) and dendritic cells (DCs) are involved in many autoimmune diseases, but the potential roles of TSLP and DCs in bullous pemphigoid (BP) have not been clarified. We sought to explore the contributions of TSLP and DCs in patients with BP.\n                    <jats:italic>Methods<\/jats:italic>\n                    . TSLP levels in sera and blister fluids were measured by enzyme\u2010linked immunosorbent assay. The TSLP expression in the BP lesional skin was detected by immunohistochemical staining. Infiltration of DCs, marked by DC\u2010specific intercellular adhesion molecule\u20103\u2010grabbing nonintegrin (DC\u2010SIGN), and its relationship with TSLP and TSLP receptors was evaluated by immunofluorescence staining.\n                    <jats:italic>Results<\/jats:italic>\n                    . We found that TSLP levels in sera and in blister fluids of patients with BP were higher compared to the control groups. In patients with BP, TSLP levels in sera correlated with TSLP levels in blisters. The expression of TSLP in the BP lesional skin was higher compared to the healthy controls\u2019 skin. Greater numbers of TSLP\u2010positive cells were observed in the epidermis of patients with BP compared to the healthy controls. Greater numbers of DC\u2010SIGN\u2010positive cells were present in the BP lesional skin compared to the skin of controls. The expression of TSLP was highly upregulated in DC\u2010SIGN\u2010positive cells, and most DC\u2010SIGN\u2010positive cells expressed TSLP receptors.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . We conclude that TSLP may activate DC\u2010SIGN\u2010positive DCs directly, which may be involved in the pathogenesis of BP.\n                  <\/jats:p>","DOI":"10.1155\/2020\/4594630","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T19:32:10Z","timestamp":1600975930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells"],"prefix":"10.1155","volume":"2020","author":[{"given":"Si-Zhe","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Xing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2526-4331","authenticated-orcid":false,"given":"Ya-Gang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-1554","authenticated-orcid":false,"given":"Hong-Zhong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12072"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.06.019"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.3357"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242654"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3523"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.07.012"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38338"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.06.010"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507052112"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1197"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.2340\/0001555567529532"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12525315"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.08.008"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2011.04.015"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.02.013"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-404717-4.00004-4"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01595"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900758"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1721805115"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01954-5"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.07.060"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141787"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.03.032"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2007.01719.x"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.12.008"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni805"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.04.022"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2020.1783242"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7281453"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.014"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.09.012"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2013.11.007"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12566"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12960"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.05.011"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.003"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxaa012"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000202"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01206.x"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/4594630.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2020\/4594630.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/4594630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:19:03Z","timestamp":1762093143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/4594630"}},"subtitle":[],"editor":[{"given":"Luis Alberto","family":"Ponce-Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/4594630"],"URL":"https:\/\/doi.org\/10.1155\/2020\/4594630","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4594630"}}