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The novel immune checkpoint coinhibitory receptor T cell Ig and ITIM domain (TIGIT) shares similar ligands as the costimulatory receptor DNAX accessory molecule 1 (DNAM\u20101) and suppresses T cell responses in tumor patients. This study is aimed at characterizing whether the TIGIT\/DNAM\u20101 axis is involved in the distribution and expression of Foxp3+ <jats:italic>\u03b3\u03b4<\/jats:italic> Treg cell subsets in acute myeloid leukemia (AML) patients of different clinical statuses: <jats:italic>de novo<\/jats:italic> AML (27 patients), AML in nonremission (NR) (7 patients), and AML in complete remission (CR) (12 patients). Our data demonstrated that the proportions of Foxp3+, TIGIT+Foxp3+, and DNAM\u20101+Foxp3+ <jats:italic>\u03b3\u03b4<\/jats:italic> T cells are significantly higher in <jats:italic>de novo<\/jats:italic> and NR patients. High levels of TIGIT and DNAM\u20101 on Foxp3+ <jats:italic>\u03b3\u03b4<\/jats:italic> T cells correlated with increased Foxp3+ <jats:italic>\u03b3\u03b4<\/jats:italic> T cell frequencies. In addition, a high TIGIT\/DNAM\u20101 ratio was observed in <jats:italic>de novo<\/jats:italic> AML patients and healthy individuals (HIs). Furthermore, the phenotypic abnormalities in Foxp3+, TIGIT+Foxp3+, and DNAM\u20101+Foxp3+ <jats:italic>\u03b3\u03b4<\/jats:italic> T cells were restored when the patients achieved CR after chemotherapy. Moreover, higher TIGIT+Foxp3+ <jats:italic>\u03b3\u03b4<\/jats:italic> T cells were associated with AML patients who had poor overall survival and were an independent risk factor for prognosis. In conclusion, our study reveals for the first time that the TIGIT\/DNAM\u20101 axis may be involved in Foxp3+ <jats:italic>\u03b3\u03b4<\/jats:italic> Treg cells and indicates the clinical progression and prognosis of AML patients of different clinical statuses, which is considered beneficial for efficient AML immunotherapy.<\/jats:p>","DOI":"10.1155\/2020\/4612952","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T23:34:14Z","timestamp":1595892854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Characteristic of TIGIT and DNAM\u20101 Expression on Foxp3+ <i>\u03b3\u03b4<\/i> T Cells in AML 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